手参块茎的糖苷成分。

Glycosidic constituents of the tubers of Gymnadenia conopsea.

作者信息

Zi Jiachen, Li Shuai, Liu Mingtao, Gan Maoluo, Lin Sheng, Song Weixia, Zhang Yanling, Fan Xiaona, Yang Yongchun, Zhang Jianjun, Shi Jiangong, Di Duolong

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, PR China.

出版信息

J Nat Prod. 2008 May;71(5):799-805. doi: 10.1021/np070670j. Epub 2008 Mar 19.

DOI:10.1021/np070670j

PMID:18348533

Abstract

Ten minor new glycosidic constituents (1- 10), together with 10 known compounds, have been isolated from a neuroprotective fraction of an ethanolic extract of the tubers of Gymnadenia conopsea. The structures of 1-10 were determined using spectroscopic and chemical methods. The compounds isolated were evaluated for activity in in vitro assays for acetylcholine esterase and monoamine oxidase inhibitory activities.

摘要

从手参块茎乙醇提取物的神经保护部分中分离出了10种新的次要糖苷类成分（1-10）以及10种已知化合物。采用光谱和化学方法确定了1-10的结构。对分离得到的化合物进行了体外乙酰胆碱酯酶和单胺氧化酶抑制活性测定。