2型单纯疱疹病毒经阴道感染和黏膜疫苗接种期间，敏感和抗性小鼠品系腹膜巨噬细胞的功能活性
Functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal infection with herpes simplex virus type 2 and mucosal vaccination.
作者信息
Nagurskaya E V, Zaitseva L G, Kobets N V, Kireeva I V, Alimbarova L M, Samoilenko I I, Barinskii I F
机构信息
N. F. Gamaleya Institute of Epidemiology, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2008 Feb;145(2):235-9. doi: 10.1007/s10517-008-0059-9.
In the early period after intravaginal infection with herpes simplex virus type 2 (2 h), macrophages from sensitive DBA/2 mice were characterized by higher capacity to engulf the antigen, decreased function of the lysosomal apparatus, lower activity of cathepsin D, and reduced oxygen metabolism compared to cells from resistant BALB/c mice. Mucosal vaccination with herpes vaccine and hyaluronic acid promoted the increase in functional activity of macrophages and improved survival of sensitive mice (by 60%).
在经阴道感染2型单纯疱疹病毒后的早期（2小时），与来自抗性BALB/c小鼠的细胞相比，敏感DBA/2小鼠的巨噬细胞具有更高的抗原吞噬能力、溶酶体装置功能降低、组织蛋白酶D活性较低以及氧代谢减少的特征。用疱疹疫苗和透明质酸进行黏膜疫苗接种可促进巨噬细胞功能活性的增加，并提高敏感小鼠的存活率（提高60%）。
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