Meyer Jonathan M
Department of Psychiatry, University of California, San Diego, San Diego VAMC, USA.
J Clin Psychiatry. 2008 Sep;69(9):e26. doi: 10.4088/jcp.0908e26.
Atypical antipsychotics can provide improvement in schizophrenic symptomatology but also may cause side effects, such as erectile dysfunction and decreased libido, which can be problematic for patients. In order to keep patients symptomatically stable and to help alleviate these side effects, clinicians should alter the treatment strategy, possibly by switching medications, to encourage adherence to the medication as well as optimize patients' outcomes. To establish clinically useful standards for switching agents, more studies are needed that focus on gradual cross-titration methods to achieve therapeutic doses for patients.
非典型抗精神病药物可以改善精神分裂症的症状,但也可能引起副作用,如勃起功能障碍和性欲减退,这对患者来说可能是个问题。为了使患者症状稳定并帮助减轻这些副作用,临床医生应改变治疗策略,可能通过更换药物,以鼓励患者坚持用药并优化治疗效果。为了建立临床上有用的换药标准,需要更多关注逐步交叉滴定方法以达到患者治疗剂量的研究。