Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Cardiovasc Pathol. 2010 Mar-Apr;19(2):e33-6. doi: 10.1016/j.carpath.2008.09.004. Epub 2008 Nov 21.
A 41-year-old male with cardiomyopathy from an inherited beta myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.
一名患有心肌病的 41 岁男性，其心肌病源自遗传性β肌球蛋白重链突变，他接受了心肌内细胞移植治疗心力衰竭。他接受了直接注射来自他血液的自体前体细胞。他立即出现心室颤动。尽管他被复苏，但他经历了一个长期的恶化过程，使他无法进行移植。他的尸检显示心肌内有明显的纤维化，伴有单核细胞浸润的区域。这个病例强调了心肌内治疗在心肌病心脏中的潜在不良影响。
