Chapes Stephen K, Ganta Roman R
Division of Biology, College of Arts and Sciences, Kansas State University, Manhattan, KS 66506, USA.
Vet Parasitol. 2008 Dec 20;158(4):344-59. doi: 10.1016/j.vetpar.2008.09.028. Epub 2008 Oct 17.
Pathogenic bacteria belonging to the family Anaplasmataceae include species of the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis, first known as the causative agent of human monocytic ehrlichiosis, also infects several vertebrate hosts including white-tailed deer, dogs, coyotes and goats. E. chaffeensis is transmitted from the bite of an infected hard tick, such as Amblyomma americanum. E. chaffeensis and other tick-transmitted pathogens have adapted to both the tick and vertebrate host cell environments. Although E. chaffeensis persists in both vertebrate and tick hosts for long periods of time, little is known about that process. Immunological studies will be valuable in assessing how the pathogen persists in nature in both vertebrate and invertebrate hosts. Understanding the host immune response to the pathogen originating from dual host backgrounds is also important to develop effective methods of diagnosis, control and treatment. In this paper, we provide our perspective of the current understanding of the immune response against E. chaffeensis in relation to other related Anaplasmataceae pathogens.
无形体科的致病细菌包括埃立克体属和无形体属的物种。查菲埃立克体最初被认为是人类单核细胞埃立克体病的病原体，它还感染包括白尾鹿、狗、郊狼和山羊在内的多种脊椎动物宿主。查菲埃立克体通过受感染的硬蜱（如美洲钝缘蜱）叮咬传播。查菲埃立克体和其他蜱传播的病原体已经适应了蜱和脊椎动物宿主细胞环境。尽管查菲埃立克体在脊椎动物和蜱宿主中都能长期存活，但对这一过程了解甚少。免疫学研究对于评估病原体如何在脊椎动物和无脊椎动物宿主中自然存活具有重要价值。了解宿主对源自双重宿主背景的病原体的免疫反应对于开发有效的诊断、控制和治疗方法也很重要。在本文中，我们阐述了目前对与其他相关无形体科病原体相关的针对查菲埃立克体的免疫反应的理解。
