Onagbesan Okanlawon, Bruggeman Veerle, Decuypere Eddy
Department of Biosystems, Catholic University, Leuven, Belgium.
Anim Reprod Sci. 2009 Apr;111(2-4):121-40. doi: 10.1016/j.anireprosci.2008.09.017. Epub 2008 Oct 8.
There is now overwhelming evidence that the avian ovary is a site of production and action of several growth factors that have also been implicated in the functioning of the mammalian ovary. Several members of the Insulin-like growth factor family (IGF), the Epidermal growth factor family (EGF), the Transforming growth factor-beta family (TGF-beta), Fibroblast growth factors (FGF), the Tumour necrosis factor-alpha (TNF-alpha), and others, have been identified either in the granulosa and/or theca compartments of ovarian follicles and in the embryonic and juvenile ovary. Some have been specifically localized to the germinal disc area containing the oocyte. The mRNAs and proteins of the growth factors, receptor proteins and binding proteins of some of the members of each group have been reported in the chicken, turkey, quail and duck. The intra-ovarian roles reported for the different growth factors include regulation of cell proliferation, steroidogenesis, follicle selection, modulation of gonadotrophin action, control of ovulation rate, cell differentiation, production of growth factors, etc. The aim of this paper is to provide a review of the current knowledge of avian ovarian growth factors and their biological activity in the ovary. The review covers the detection of the growth factor proteins, the receptor proteins, binding proteins, their spatial and temporal distribution in embryonic, juvenile and adult ovaries and their regulation. The paper also discusses their roles in each follicular compartment during follicular development. Greater emphasis is given to the major growth factors that have been studied to greater detail and others are discussed very briefly.
目前有大量证据表明，禽类卵巢是多种生长因子的产生和作用部位，这些生长因子也与哺乳动物卵巢的功能有关。胰岛素样生长因子家族（IGF）、表皮生长因子家族（EGF）、转化生长因子-β家族（TGF-β）、成纤维细胞生长因子（FGF）、肿瘤坏死因子-α（TNF-α）等家族的多个成员已在卵泡的颗粒细胞和/或膜细胞区室以及胚胎期和幼年期卵巢中被鉴定出来。有些因子已被特异性定位到含有卵母细胞的胚盘区域。鸡、火鸡、鹌鹑和鸭中已报道了每组中一些成员的生长因子、受体蛋白和结合蛋白的mRNA及蛋白质。报道的不同生长因子在卵巢内的作用包括调节细胞增殖、类固醇生成、卵泡选择、调节促性腺激素作用、控制排卵率、细胞分化、生长因子的产生等。本文旨在综述禽类卵巢生长因子及其在卵巢中的生物学活性的现有知识。该综述涵盖了生长因子蛋白、受体蛋白、结合蛋白的检测，它们在胚胎期、幼年期和成年期卵巢中的时空分布及其调节。本文还讨论了它们在卵泡发育过程中在每个卵泡区室中的作用。更详细地研究了主要生长因子，并简要讨论了其他生长因子。
