没有证据表明干扰素调节因子1（IRF1）基因与临床结核病之间存在关联。

No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis.

作者信息

Vollstedt Sabine, Yuliwulandari Rika, Okamoto Koji, Lien Luu Thi, Keicho Naoto, Rochani Jecti Teguh, Wikaningrum Riyani, Tokunaga Katsushi

机构信息

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan.

出版信息

Tuberculosis (Edinb). 2009 Jan;89(1):71-6. doi: 10.1016/j.tube.2008.09.006. Epub 2008 Nov 22.

DOI:10.1016/j.tube.2008.09.006

PMID:19028144

Abstract

Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned out not to be associated with pulmonary tuberculosis.

摘要

干扰素调节因子1是一种转录因子，在结核分枝杆菌感染期间参与启动强烈的Th1反应。因此，我们认为它是某些多态性的一个可能候选基因，这些多态性可能导致个体易患临床结核病。然而，在两个东南亚人群（印度尼西亚人和越南人）中，所有次要等位基因频率高于5%的多态性和单倍型频率均与肺结核无关。