Hatta Mochammad, Tanaka Motoko, Ito Jun, Shirakawa Toshiro, Kawabata Masato
Department of Medical Microbiology, Molecular Biology and Immunology Laboratory, Faculty Medicine, Hasanuddin University, Makassar, Indonesia.
Southeast Asian J Trop Med Public Health. 2010 Mar;41(2):386-94.
Genetic host factor may play an important role in controlling mycobacterial infections such as tuberculosis and leprosy. Natural resistance associated macrophage protein1 (Nramp1, alias Slc11a1) gene has been suggested to an associated gene of the host susceptibility to mycobacterium infection. To determine the association of Nramp1/Slc11a1 with tuberculosis and leprosy, we analyzed using polymerase chain reaction restriction fragment length polymorphisms three variants (D543N, 3'UTR and INT4) of Nramp1/Slc11a1 gene in 58 tuberculosis patients (mean age, 34.0 +/- 13.1), 42 leprosy patients (mean age, 35.0 +/- 14.3) and 198 healthy controls (mean age, 32.0 +/- 12.9) from South Sulawesi, Indonesia. We observed an association of INT4 polymorphism with paucibacillary type of leprosy (p = 0.032, 1df, OR = 2.975, CI = 1.057-8.373), but not to multibacillary type (p = 0.173, 1df, OR = 2.248, CI = 0.682-7.404). No significant association was found in the three variants with tuberculosis in this population.
遗传宿主因素可能在控制结核和麻风等分枝杆菌感染中发挥重要作用。天然抗性相关巨噬细胞蛋白1（Nramp1，别名Slc11a1）基因被认为是宿主对分枝杆菌感染易感性的相关基因。为了确定Nramp1/Slc11a1与结核病和麻风病的关联，我们使用聚合酶链反应-限制性片段长度多态性分析了来自印度尼西亚南苏拉威西的58例结核病患者（平均年龄34.0±13.1岁）、42例麻风病患者（平均年龄35.0±14.3岁）和198例健康对照者（平均年龄32.0±12.9岁）的Nramp1/Slc11a1基因的三个变体（D543N、3'UTR和INT4）。我们观察到INT4多态性与少菌型麻风病相关（p = 0.032，1自由度，OR = 2.975，CI = 1.057 - 8.373），但与多菌型无关（p = 0.173，1自由度，OR = 2.248，CI = 0.682 - 7.404）。在该人群中，未发现这三个变体与结核病有显著关联。
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