Vaisi-Raygani Asad, Tavilani Heidar, Zahrai Mahine, Rahimi Zohreh, Sheikh Nasrin, Aminian Mahdi, Pourmotabbed Tayebeh
Department of Clinical Biochemistry, Fertility Infertility Research Center, Faculty of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran.
Clin Biochem. 2009 Feb;42(3):210-4. doi: 10.1016/j.clinbiochem.2008.10.025. Epub 2008 Nov 12.
Butyrylcholinesterase (BuChE) catalyzes the hydrolysis of acetylcholine and other choline esters and is also involved in lipid metabolism. The purpose of this study was to investigate any association between BuChE serum phenotype and activity and lipid profile of ischemic stroke patients.
We determined serum BuChE activities and phenotypes, and levels of total cholesterol (TC), LDL-C, HDL-C and triacylglyerol (TG) in 33 patients with acute ischemic stroke within 12 h of the onset of the attack and 29 controls.
The mean (+/-SD) serum BuChE activity and the BuChE of U/A phenotype in the stroke individuals were significantly lower and higher than that of the control (315 (+/-124) IU/L. vs. 384 (+/-99) IU/L, p=0.02, t=-2.4 and 21.2% vs.3.4%, p=0.026 respectively).
Our results showed that a negative correlation between BuChE activity with TC level, in addition the frequency of BuChE phenotypes with low activity is high in stroke patients, who have high levels of cholesterol, may have increased susceptibility to stroke.
丁酰胆碱酯酶（BuChE）催化乙酰胆碱和其他胆碱酯的水解，还参与脂质代谢。本研究旨在探讨缺血性中风患者的BuChE血清表型、活性与血脂谱之间的关联。
我们测定了33例急性缺血性中风发作12小时内患者及29例对照者的血清BuChE活性、表型以及总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）水平。
中风患者的平均（±标准差）血清BuChE活性及U/A表型的BuChE显著低于和高于对照组（分别为315（±124）IU/L对384（±99）IU/L，p = 0.02，t = -2.4；21.2%对3.4%，p = 0.026）。
我们的结果表明，BuChE活性与TC水平呈负相关，此外，胆固醇水平高的中风患者中低活性BuChE表型的频率较高，可能对中风的易感性增加。
