Monchanin Geraldine, Serpero Laura D, Connes Philippe, Tripette Julien, Wouassi Dieudonné, Francina Alain, Massarelli Raphael, Gozal David, Thiriet Patrice, Martin Cyril
EA 647 Center of Research and Innovation on Sports, Claude Bernard University of Lyon 1, and Unity of Hemoglobin Molecular Pathology, Edouard Herriot Hospital, Lyon, France.
Clin Hemorheol Microcirc. 2008;40(2):89-97.
The aim of the study was to examine the effects of endurance exercise on circulating vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in sickle cell trait (SCT) athletes with or without alpha-thalassemia. Five athletes with SCT, 7 athletes with both SCT and alpha-thalassemia (SCTAT) and 8 control athletes (CONT) performed an incremental test on cycloergometer followed 72 hours later by a 60-min endurance exercise with a workload set at 70% P(peak) (peak power). We assessed levels of sICAM-1, sVCAM-1 and TNF-alpha at rest, immediately after endurance exercise and 1, 2, and 24 hours of recovery. Although, CONT and SCTAT groups exhibited similar basal plasma levels of adhesion molecules and TNF-alpha, SCT group had higher sVCAM-1 basal concentrations. No significant variation in sVCAM-1, sICAM-1 and TNF-alpha was measured following endurance exercise. Consequently, sVCAM-1 remained elevated in the SCT group after exercise and during the recovery period. In conclusion, our findings support the concept that SCT athletes might be at risk for microcirculatory disturbances, but these adhesive processes were not further impaired in response to endurance exercise. In addition, alpha-thalassemia co existing trait may be protective both at rest and after endurance exercise in SCT subjects.
本研究的目的是检验耐力运动对患有或未患有α地中海贫血的镰状细胞性状（SCT）运动员循环血管细胞黏附分子-1（sVCAM-1）和细胞间黏附分子-1（sICAM-1）的影响。5名患有SCT的运动员、7名同时患有SCT和α地中海贫血（SCTAT）的运动员以及8名对照运动员（CONT）在蹬车测力计上进行递增测试，72小时后进行60分钟的耐力运动，运动负荷设定为峰值功率（P(peak)）的70%。我们在静息状态、耐力运动结束后即刻以及恢复1、2和24小时后评估sICAM-1、sVCAM-1和肿瘤坏死因子-α（TNF-α）的水平。尽管CONT组和SCTAT组的黏附分子和TNF-α基础血浆水平相似，但SCT组的sVCAM-1基础浓度更高。耐力运动后未检测到sVCAM-1、sICAM-1和TNF-α有显著变化。因此，SCT组在运动后及恢复期间sVCAM-1仍保持升高。总之，我们的研究结果支持这样的观点，即SCT运动员可能存在微循环紊乱的风险，但这些黏附过程在耐力运动后并未进一步受损。此外，共存的α地中海贫血性状在SCT受试者静息时和耐力运动后可能具有保护作用。
