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同步双波段超高分辨率全场光学相干断层扫描术

Simultaneous dual-band ultra-high resolution full-field optical coherence tomography.

作者信息

Sacchet Delphine, Moreau Julien, Georges Patrick, Dubois Arnaud

机构信息

Laboratoire Charles Fabry de l'Institut d'Optique, CNRS UMR 8501, Université Paris-Sud, Campus Polytechnique, RD128, 91127 Palaiseau Cedex, France.

出版信息

Opt Express. 2008 Nov 24;16(24):19434-46. doi: 10.1364/oe.16.019434.

Abstract

Ultrahigh-resolution full-field optical coherence tomography (FF-OCT) is demonstrated in the 800 nm and 1200 nm wavelength regions simultaneously using a Silicon-based (Si) CCD camera and an Indium Gallium Arsenide (InGaAs) camera as area detectors and a halogen lamp as illumination source. The FF-OCT setup is optimized to support the two broad spectral bands in parallel, achieving a detection sensitivity of approximately 90 dB and a micrometer-scale resolution in the three directions. Images of ex vivo biological tissues are presented (rabbit trachea and Xenopus laevis tadpole) with an increase in penetration depth at 1200 nm. A color image representation is applied to fuse both images and enhance spectroscopic property visualization.

摘要

利用硅基(Si)电荷耦合器件(CCD)相机和砷化铟镓(InGaAs)相机作为面探测器,以及卤钨灯作为照明源,在800纳米和1200纳米波长区域同时展示了超高分辨率全场光学相干断层扫描(FF-OCT)。FF-OCT装置经过优化,以并行支持两个宽光谱带,在三个方向上实现了约90分贝的检测灵敏度和微米级分辨率。展示了离体生物组织(兔气管和非洲爪蟾蝌蚪)的图像,在1200纳米处穿透深度有所增加。采用彩色图像表示法融合这两幅图像并增强光谱特性可视化。

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