降钙素原作为血液肿瘤发热患者感染的有用标志物。
Procalcitonin as a useful marker of infection in hemato-oncological patients with fever.
作者信息
Sandri Maria T, Passerini Rita, Leon Maria E, Peccatori Fedro A, Zorzino Laura, Salvatici Michela, Riggio Daniela, Cassatella Cristina, Cinieri Saverio, Martinelli Giovanni
机构信息
Laboratory Medicine Unit, European Institute of Oncology, Milan, Italy.
出版信息
Anticancer Res. 2008 Sep-Oct;28(5B):3061-5.
BACKGROUND
The diagnostic utility of procalcitonin (PCT) and C-reactive protein (CRP) to discriminate between infective fever and fever due to inflammation was assessed in hemato-oncological patients treated with aggressive chemotherapy.
PATIENTS AND METHODS
Values of PCT and PCR measured on days -1, 0, 1, 3 and 5 of onset of fever were analyzed using longitudinal regression analysis. Of 236 febrile episodes in 166 patients, 39 were due to bacteremia, 62 to other infections and 135 were classified as fever of unknown origin.
RESULTS
PCT concentration increased early only in bacteremia and other infections (p<0.001), with the highest levels at day +1. No different trends were noted in patients with low WBC count (<1,000/microl). CRP increased with a similar trend in all the three groups.
CONCLUSION
PCT determination may contribute significantly to the management of hemato-oncological patients who experience febrile episodes.
背景
在接受强化化疗的血液肿瘤患者中，评估降钙素原（PCT）和C反应蛋白（CRP）在鉴别感染性发热和炎症性发热方面的诊断效用。
患者与方法
使用纵向回归分析对发热开始后第-1、0、1、3和5天测得的PCT和PCR值进行分析。166例患者发生236次发热事件，其中39次由菌血症引起，62次由其他感染引起，135次归类为不明原因发热。
结果
仅在菌血症和其他感染中，PCT浓度早期升高（p<0.001），在第+1天达到最高水平。白细胞计数低（<1000/微升）的患者未观察到不同趋势。三组中CRP均以相似趋势升高。
结论
PCT测定可能对发生发热事件的血液肿瘤患者的管理有显著帮助。
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