Huang C-J, Liu H-F, Su N-Y, Hsu Y-W, Yang C-H, Chen C-C, Tsai P-S
Department of Anaesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.
Anaesthesia. 2008 Dec;63(12):1288-95. doi: 10.1111/j.1365-2044.2008.05760.x.
This study examined the association between pressure pain sensitivity and various single nucleotide polymorphisms (SNPs) of human micro-, kappa-, and delta-opioid receptor (i.e. OPRM1, OPRK1, and OPRD1) genes in 72 healthy adult Taiwanese women of Han Chinese race. Pressure pain threshold and tolerance were measured by an algometer and polymorphisms of the opioid receptor genes determined from blood samples. Our data revealed that pressure pain threshold, but not tolerance, in subjects with the minor allele (termed 'GA') genotype of the IVS2+31G>A polymorphism of the OPRM1 gene was significantly higher than those with major allele (termed 'GG') genotype. Neither pressure pain threshold nor tolerance between major and minor alleles of other SNPs of the OPRM1, OPRK1, and OPRD1 genes were significantly different. These data suggest an association between the IVS2+31G>A SNP of the OPRM1 gene and pressure pain sensitivity in healthy adult females.
本研究调查了72名汉族台湾健康成年女性中，压痛敏感性与人类μ-、κ-和δ-阿片受体（即OPRM1、OPRK1和OPRD1）基因的各种单核苷酸多态性（SNP）之间的关联。通过压力痛觉计测量压痛阈值和耐受性，并从血样中确定阿片受体基因的多态性。我们的数据显示，携带OPRM1基因IVS2+31G>A多态性次要等位基因（称为“GA”）基因型的受试者的压痛阈值显著高于携带主要等位基因（称为“GG”）基因型的受试者，但耐受性无显著差异。OPRM1、OPRK1和OPRD1基因其他SNP的主要和次要等位基因之间的压痛阈值和耐受性均无显著差异。这些数据表明，OPRM1基因的IVS2+31G>A SNP与健康成年女性的压痛敏感性之间存在关联。
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