Xie X, Webber C E, Adachi J D, O'Neill J, Inglis D, Bobba R S, Wu H
Department of Radiation Oncology, Ontario Cancer Institute, Princes Margaret Hospital, Toronto, Ontario, Canada.
Clin Exp Rheumatol. 2008 Sep-Oct;26(5):860-5.
To determine if quantitative hand images obtained from an office-based MRI extremity scanner reliably distinguish patients with rheumatoid arthritis from controls.
The hands of 39 patients suffering from rheumatoid arthritis were imaged using a small bore, 1.0 Tesla Magnetic Resonance Imager. Non-contrast images of the metacarpophalangeal joints and wrist joints were evaluated using a method based on the validated rheumatoid arthritis magnetic resonance imaging system (RAMRIS). The extent and degree of synovitis, bone edema and bone erosions was assessed. Derived scores were compared with the corresponding scores for groups of younger (n=14) and older (n=27) controls with no signs or symptoms of joint disease.
The mean (+/-standard error) total joint scores were 0.3+/-0.2 for young controls, 11.5+/-2.4 for older controls and 34.1+/-6.0 for the patients with rheumatoid arthritis. The greatest difference between rheumatoid patients and older controls was observed for synovitis with scores that were greater by a factor of almost 6.5. Scores for erosions and edema were factors of 2.9 and 2.3 greater in rheumatoid arthritis than in controls. The relationship between scores for the same joints on the dominant and non-dominant sides was generally stronger than the relationship between the metacarpophalangeal and wrist joints of the same hand.
These observations indicate that scoring of hand images obtained from a small bore, office based, 1.0 Tesla MR imager have clinical validity and may be used to distinguish patients with rheumatoid arthritis from aged matched controls.
确定从基于办公室的MRI四肢扫描仪获得的手部定量图像能否可靠地区分类风湿性关节炎患者与对照组。
使用小口径1.0特斯拉磁共振成像仪对39例类风湿性关节炎患者的手部进行成像。使用基于经过验证的类风湿性关节炎磁共振成像系统（RAMRIS）的方法评估掌指关节和腕关节的非对比图像。评估滑膜炎、骨水肿和骨侵蚀的程度和范围。将得出的分数与无关节疾病体征或症状的年轻（n = 14）和老年（n = 27）对照组的相应分数进行比较。
年轻对照组的平均（±标准误差）总关节评分为0.3±0.2，老年对照组为11.5±2.4，类风湿性关节炎患者为34.1±6.0。类风湿性关节炎患者与老年对照组之间在滑膜炎方面的差异最大，分数几乎高出6.5倍。类风湿性关节炎患者的侵蚀和水肿分数分别比对照组高2.9倍和2.3倍。优势侧和非优势侧相同关节的分数之间的关系通常比同一只手的掌指关节和腕关节之间的关系更强。
这些观察结果表明，从小口径、基于办公室的1.0特斯拉MR成像仪获得的手部图像评分具有临床有效性，可用于区分类风湿性关节炎患者与年龄匹配的对照组。
