日本早期类风湿关节炎患者的抗葡萄糖-6-磷酸异构酶、抗环瓜氨酸肽抗体及HLA-DRB1基因型

Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis.

作者信息

Furuya T, Matsumoto I, Tsuchiya N, Hakoda M, Ichikawa N, Yago T, Higami K, Nanke Y, Sumida T, Kamatani N, Kotake S

机构信息

Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.

出版信息

Clin Exp Rheumatol. 2008 Sep-Oct;26(5):918-21.

PMID:19032829

Abstract

OBJECTIVE

Our goal was to evaluate the associations of antibodies (Abs) to glucose-6-phosphate isomerase (GPI) with Abs to cyclic citrullinated peptide (CCP) and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis (RA).

METHODS

One hundred and eight patients with early RA (85 female, 23 male) who visited our clinic within 1 year of symptom onset were examined for anti-GPI and anti-CCP Ab levels, and HLA-DRB1 genotype. Anti-GPI and anti-CCP Ab levels, and HLA-DRB1 genotypes were also determined in 63 controls and 265 healthy controls, respectively.

RESULTS

Of the 108 patients with early RA and the 63 controls, 20 (18.5%) and 3 (4.8%) were anti-GPI Ab-positive, respectively. Of the 20 patients with anti-GPI Abs, 17 (85%) were positive for anti-CCP Abs. HLA-DRB10405 and shared epitope (SE) carrier frequencies were significantly increased not only in anti-GPI Ab-positive patients (p=0.00057, odds ratio [OR] 4.6, 95% CI 1.8-11.8; p=0.0011, OR 5.0, 95% CI 1.7-14.0), but also in anti-GPI Ab-negative patients (p=0.0017, OR 2.2, 95% CI 1.3-3.7; p=0.00011, OR 2.6, 95% CI 1.6-4.3), when compared with controls. In addition, the carrier frequency of HLA-DRB11201 was significantly increased in anti-GPI Ab-positive patients compared with controls (p=0.0056, OR 4.3, 95% CI 1.4-13.2).

CONCLUSIONS

The majority of anti-GPI Ab-positive RA patients constitute a subset of HLA-DRB1* SE-associated, anti-CCP Ab-positive RA patients.

摘要

目的

我们的目标是评估日本早期类风湿关节炎（RA）患者中葡萄糖-6-磷酸异构酶（GPI）抗体（Abs）与环瓜氨酸肽（CCP）抗体及HLA - DRB1基因型之间的关联。

方法

对症状出现1年内就诊于我们诊所的108例早期RA患者（85例女性，23例男性）检测抗GPI和抗CCP抗体水平以及HLA - DRB1基因型。同时分别对63例对照和265例健康对照检测抗GPI和抗CCP抗体水平以及HLA - DRB1基因型。

结果

在108例早期RA患者和63例对照中，分别有20例（18.5%）和3例（4.8%）抗GPI抗体呈阳性。在20例抗GPI抗体阳性的患者中，17例（85%）抗CCP抗体呈阳性。与对照相比，不仅抗GPI抗体阳性患者中HLA - DRB10405和共同表位（SE）携带者频率显著增加（p = 0.00057，优势比[OR] 4.6，95%可信区间[CI] 1.8 - 11.8；p = 0.0011，OR 5.0，95% CI 1.7 - 14.0），抗GPI抗体阴性患者中也是如此（p = 0.0017，OR 2.2，95% CI 1.3 - 3.7；p = 0.00011，OR 2.6，95% CI 1.6 - 4.3）。此外，与对照相比，抗GPI抗体阳性患者中HLA - DRB11201的携带者频率显著增加（p = 0.0056，OR 4.3，95% CI 1.4 - 13.2）。