Leacche Marzia, Balaguer Jorge M, Byrne John G
Vanderbilt Heart and Vascular Institute, Department of Cardiac Surgery, 1215 21st Avenue South, MCE 5th Floor, South Tower, Nashville, TN 37232, USA.
Curr Heart Fail Rep. 2008 Dec;5(4):204-10. doi: 10.1007/s11897-008-0031-z.
Limited donor availability for orthotopic cardiac transplantation has led surgeons to develop surgical alternatives to treat congestive heart failure as a result of ischemic cardiomyopathy. Coronary revascularization plays a clear role in patients with ischemic cardiomyopathy, substantial viable myocardium subtended by coronary stenoses, and presence of anginal symptoms. It is unclear whether patients with heart failure symptoms but no angina benefit from bypass surgery. Some of these patients present with left ventricular dilatation and akinetic/dyskinetic scars, and are therefore candidates for surgical ventricular restoration. Current evidence is lacking as to whether ventricular reconstruction should be performed along with coronary revascularization. Functional mitral regurgitation is often seen in patients with end-stage cardiomyopathy, and its presence portends decreased survival. Mitral valve repair has been shown to improve quality of life, functional class, and to contribute to left ventricle reverse remodeling; however, it has been insufficient in improving survival.
原位心脏移植供体有限,促使外科医生开发手术替代方案来治疗缺血性心肌病导致的充血性心力衰竭。冠状动脉血运重建对于患有缺血性心肌病、存在由冠状动脉狭窄引起的大量存活心肌且有心绞痛症状的患者具有明确作用。目前尚不清楚有心力衰竭症状但无心绞痛的患者是否能从搭桥手术中获益。其中一些患者表现为左心室扩张以及运动不能/运动障碍性瘢痕,因此是手术性心室修复的候选者。目前缺乏关于心室重建是否应与冠状动脉血运重建同时进行的证据。功能性二尖瓣反流在终末期心肌病患者中很常见,其存在预示着生存率降低。二尖瓣修复已被证明可改善生活质量、功能分级,并有助于左心室逆向重塑;然而,在提高生存率方面还不够充分。