Heeringa Jan, Kors Jan A, Hofman Albert, van Rooij Frank J A, Witteman Jacqueline C M
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Am Heart J. 2008 Dec;156(6):1163-9. doi: 10.1016/j.ahj.2008.08.003. Epub 2008 Oct 14.
Cigarette smoking is an important risk factor for cardiovascular disease, but it is unknown whether it also contributes to the risk of atrial fibrillation.
The study is part of the Rotterdam Study, a population-based cohort study among subjects aged > or =55 years. The association between cigarette smoking and the risk of atrial fibrillation was examined in 5,668 subjects without atrial fibrillation at baseline. During a median follow-up of 7.2 years, 371 cases of atrial fibrillation were identified. Relative risks (RR) were calculated with 95% CIs using the Cox proportional hazards model, adjusted for age, gender, body mass index, hypertension, systolic blood pressure, serum cholesterol level, diabetes mellitus, left ventricular hypertrophy on the electrocardiogram, prevalent and incident myocardial infarction, prevalent heart failure, and the use of pulmonary medication. After multivariate adjustment, current smokers and former smokers had increased risks of atrial fibrillation as compared to never smokers (RR 1.51, 95% CI 1.07-2.12; and RR 1.49, 95% CI 1.14-1.97, respectively). No differences were found between men and women.
The results of this prospective, population-based study show that current and former smoking of cigarettes are associated with increased risk of atrial fibrillation.
吸烟是心血管疾病的重要危险因素，但吸烟是否也会增加心房颤动的风险尚不清楚。
本研究是鹿特丹研究的一部分，这是一项针对年龄≥55岁人群的基于人群的队列研究。在5668名基线时无房颤的受试者中，研究了吸烟与房颤风险之间的关联。在中位随访7.2年期间，共确诊371例房颤病例。使用Cox比例风险模型计算相对风险（RR）及95%可信区间（CI），并对年龄、性别、体重指数、高血压、收缩压、血清胆固醇水平、糖尿病、心电图显示的左心室肥厚、既往及新发心肌梗死、既往心力衰竭以及使用肺部药物等因素进行了校正。多因素校正后，与从不吸烟者相比，当前吸烟者和既往吸烟者发生房颤的风险增加（RR分别为1.51，95%CI 1.07 - 2.12；RR为1.49，95%CI 1.14 - 1.97）。男性和女性之间未发现差异。
这项基于人群的前瞻性研究结果表明，当前吸烟和既往吸烟均与房颤风险增加有关。
