Bold Bayarkhuu, Piao Yongnan, Murata Yuji, Kishino Mitsuhiro, Shibuya Hitoshi
Department of Radiology, Tokyo Medical and Dental University, Tokyo, Japan.
Clin Nucl Med. 2008 Dec;33(12):831-3. doi: 10.1097/RLU.0b013e31818bf27d.
Patients with squamous cell carcinoma of the head and neck have been reported to have a high rate of second primary cancer of the upper aerodigestive tract. This study was performed to determine whether positron emission tomography/computed tomography (PET/CT) is useful for detecting a second primary cancer after treatment for squamous cell carcinoma of the head and neck.
The PET/CT findings in 279 consecutive patients (211 men, 68 women; mean age 62 years) who had been treated for squamous cell carcinomas of the head and neck were examined and compared with the findings obtained by other imaging modalities, the biopsy results, and the clinical data.
Thirty second primary cancers were documented in 28 of the 279 subjects. Based on PET/CT findings, the overall risk of a second primary cancer in 1 year was 9.9% and the risk in the upper aerodigestive tract region was 6.8% (19/279).
PET/CT enabled early detection of a second cancer in patients treated for head and neck cancer.
据报道，头颈部鳞状细胞癌患者上消化道发生第二原发性癌症的几率很高。本研究旨在确定正电子发射断层扫描/计算机断层扫描（PET/CT）是否有助于检测头颈部鳞状细胞癌治疗后的第二原发性癌症。
对279例连续接受过头颈部鳞状细胞癌治疗的患者（211例男性，68例女性；平均年龄62岁）的PET/CT检查结果进行了分析，并与其他成像方式的检查结果、活检结果及临床数据进行了比较。
279例受试者中有28例被诊断出30例第二原发性癌症。根据PET/CT检查结果，1年内发生第二原发性癌症的总体风险为9.9%，上消化道区域的风险为6.8%（19/279）。
PET/CT能够对头颈部癌患者的第二原发性癌症进行早期检测。
