氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描作为癌症患者第二原发性癌症的筛查工具。
F-fluorodeoxyglucose positron emission tomography-computed tomography as a screening tool for second primary cancers in cancer patients.
作者信息
Liu Yang, Ma Jie, Liu Yingxin
机构信息
Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Department of Radiology, Cancer Hospital of Guangxi Medical University, Nanning, People's Republic of China.
出版信息
Oncotarget. 2017 Sep 30;8(54):92555-92560. doi: 10.18632/oncotarget.21444. eCollection 2017 Nov 3.
BACKGROUND
We performed a meta-analysis to evaluate the value of F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) for the detection of second primary cancers in cancer patients.
RESULTS
This present study analyzed a total of 6 selected studies (1374 patients). The sensitivity and specificity of PET-CT were 0.84 (95% confidence interval [CI] = 0.66 to 0.93), and 0.98 (95% CI = 0.97 to 0.98). Area under the curve was 0.98 (95% CI = 0.96 to 0.99).
METHODS
Studies were systematically searched for relevant PET-CT original articles in the MEDLINE and EMBASE databases. We calculated the pooled sensitivity, specificity, and likelihood ratios for FDG PET-CT. We also constructed the summary receiver-operating characteristic curve for FDG PET-CT.
CONCLUSIONS
FDG PET-CT has high sensitivity and specificity for the detection of second primary cancers in cancer patients.
背景
我们进行了一项荟萃分析，以评估F-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（FDG PET-CT）在癌症患者中检测第二原发性癌症的价值。
结果
本研究共分析了6项入选研究（1374例患者）。PET-CT的敏感性和特异性分别为0.84（95%置信区间[CI]=0.66至0.93）和0.98（95%CI=0.97至0.98）。曲线下面积为0.98（95%CI=0.96至0.99）。
方法
在MEDLINE和EMBASE数据库中系统检索相关PET-CT原始文章。我们计算了FDG PET-CT的合并敏感性、特异性和似然比。我们还构建了FDG PET-CT的汇总接受者操作特征曲线。
结论
FDG PET-CT在癌症患者中检测第二原发性癌症具有高敏感性和特异性。
Zotero 插件