新西兰肥胖小鼠瘦素活性受损：血管生成模型。
Impaired leptin activity in New Zealand Obese mice: model of angiogenesis.
机构信息
Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a, 31-501, Cracow, Poland,
出版信息
Genes Nutr. 2008 Dec;3(3-4):177-80. doi: 10.1007/s12263-008-0103-4. Epub 2008 Nov 26.
Abstract
Leptin is prompt to drive angiogenesis, effecting proper vascularisation. Tissue remodeling (including adipose organ) is associated with the angiogenic response. The aim of this study was to investigate the effect of hyperleptinemia on angiogenesis in subcutaneous (s.c.) in vivo matrigel model in mice on a high fat (HF) diet. HF promoted adipose tissue accumulation and biochemical changes resembling metabolic syndrome. However, the impact of this dietary treatment on angiogenesis, measured in s.c. matrigel model was not significant. Changes in leptin concentration were not accompanied by significant angiogenic response. This lack of leptin activity and impaired signal transduction at the molecular level suggests malfunction of the leptin receptor in NZO mice.
摘要
瘦素能促进血管生成，从而实现血管的正常生成。组织重塑（包括脂肪组织）与血管生成反应有关。本研究旨在探讨高脂饮食（HF）喂养下肥胖症小鼠体内皮下（s.c.）基质胶模型中瘦素对血管生成的影响。HF 促进了脂肪组织的积累和类似代谢综合征的生化变化。然而，这种饮食处理对 s.c.基质胶模型中血管生成的影响并不显著。瘦素浓度的变化并没有伴随着明显的血管生成反应。这种瘦素活性的缺乏和分子水平上信号转导的受损表明 NZO 小鼠的瘦素受体功能障碍。
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1
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2
Signal transduction of sphingosine-1-phosphate G protein-coupled receptors.
ScientificWorldJournal. 2006 Aug 11;6:946-66. doi: 10.1100/tsw.2006.182.
3
Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells.
Carcinogenesis. 2007 Jan;28(1):28-37. doi: 10.1093/carcin/bgl085. Epub 2006 Jun 13.
4
Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.
Physiol Genomics. 2006 Apr 13;25(2):234-41. doi: 10.1152/physiolgenomics.00252.2005.
5
Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity.
Res Vet Sci. 2006 Apr;80(2):127-32. doi: 10.1016/j.rvsc.2005.05.011. Epub 2005 Jul 26.
6
Adiponectin: protection of the endothelium.
Curr Diab Rep. 2005 Aug;5(4):254-9. doi: 10.1007/s11892-005-0019-y.
7
Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values.
Br J Nutr. 2004 Feb;91(2):295-301. doi: 10.1079/bjn20031054.
8
Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells.
J Biol Chem. 2004 Jan 9;279(2):1304-9. doi: 10.1074/jbc.M310389200. Epub 2003 Oct 13.
9
Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.
Biochem Biophys Res Commun. 2003 May 16;304(4):812-7. doi: 10.1016/s0006-291x(03)00664-8.
10
High glucose dialysis solutions increase synthesis of vascular endothelial growth factors by peritoneal vascular endothelial cells.
Perit Dial Int. 2001;21 Suppl 3:S35-40.
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