两性霉素B治疗111例血液系统疾病伴中性粒细胞减少患者侵袭性真菌感染的临床研究

[Clinical study of amphotericin B in the treatment of invasive fungal infection in 111 hematological disorder patients with neutrocytopenia].

作者信息

Tong Hong-yan, Zhang Feng-juan, Xiao Feng, Qian Wen-bin, Meng Hai-tao, Mai Wen-yuan, Tong Yin, Mao Li-ping, Jin Jie

机构信息

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2008 Jul;29(7):472-5.

PMID:19035181

Abstract

OBJECTIVE

To compare the differences in clinical therapeutic effect and safety between amphotericin B and its liposome form in treating invasive fungal infection (IFI) in hematological disorder with neutrocytopenia.

METHODS

Of 111 patients with IFI, 82 were treated with amphotericin B and 29 with amphotericin B liposome. The mean cumulative dose of amphotericin B was 617 (60-1895) mg and the mean course was 18 (7-60) d, and those for amphotericin B liposome was 925 (140-3420) mg and 13 (7-50) d, respectively.

RESULTS

The total effective rates of amphotericin B and its liposome groups were 69% and 58%, respectively (P>0.05). The adverse effect rates of chill and fever in amphotericin B and its liposome groups were 21% and 10% (P>0.05), hypopotassemia 34% and 14% (P=0.03), hepatic impairment 22% and 17% (P>0.05), and renal impairment 9% and 3%, respectively (P>0.05).

CONCLUSION

The therapeutic effect for IFI of amphotericin B and its liposome was similar. The severe adverse reaction of amphotericin B liposome was slightly lower than that of amphotericin B.

摘要

目的

比较两性霉素B及其脂质体剂型治疗血液系统疾病伴中性粒细胞减少症患者侵袭性真菌感染（IFI）的临床疗效及安全性差异。

方法

111例IFI患者中，82例接受两性霉素B治疗，29例接受两性霉素B脂质体治疗。两性霉素B的平均累积剂量为617（60 - 1895）mg，平均疗程为18（7 - 60）天；两性霉素B脂质体的平均累积剂量为925（140 - 3420）mg，平均疗程为13（7 - 50）天。

结果

两性霉素B组和两性霉素B脂质体组的总有效率分别为69%和58%（P>0.05）。两性霉素B组和两性霉素B脂质体组寒战、发热的不良反应发生率分别为21%和10%（P>0.05），低钾血症分别为34%和14%（P = 0.03），肝功能损害分别为22%和17%（P>0.05），肾功能损害分别为9%和3%（P>0.05）。