一种用于抗癌药物棉酚的脂质体递送载体。
A liposomal delivery vehicle for the anticancer agent gossypol.
作者信息
Zhai Guangxi, Wu Jun, Zhao Xiaobin, Yu Bo, Li Hong, Lu Yanhui, Ye Weiping, Lin Young C, Lee Robert J
机构信息
College of Pharmacy, Shandong University, Jinan 250012, P. R. China.
出版信息
Anticancer Res. 2008 Sep-Oct;28(5A):2801-5.
BACKGROUND
Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol.
MATERIALS AND METHODS
Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity.
RESULTS
Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells.
CONCLUSION
Liposomes can be used effectively as gossypol carriers.
背景
棉酚最近被确定为一种潜在的抗癌剂。在本研究中，评估了一种新型脂质体制剂用于棉酚的递送。
材料与方法
将棉酚包封于脂质体中。对脂质体的物理和化学性质以及体外细胞毒性进行了表征。
结果
棉酚稳定地包封于这些脂质体中，并对癌细胞表现出细胞毒性。
结论
脂质体可有效地用作棉酚载体。
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