Liu Jian-Miao, Kusinski Michal, Ilic Vesna, Bignon Jérôme, Hajem Neila, Komorowski Jan, Kuzdak Krzysztof, Stepien Henryk, Wdzieczak-Bakala Joanna
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Anticancer Res. 2008 Sep-Oct;28(5A):2813-7.
The natural tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), generated from thymosin beta4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP and the activity of POP were examined in different human solid malignancies.
The expression of AcSDKP and the activity of POP were evaluated in human blood samples and tissue specimens of thyroid goiter and thyroid papillary carcinoma as well as in commercial cancer tissue microarray.
A significantly increased concentration of AcSDKP in intratumoral blood and enhanced tissular activity of POP were detected in cancer patients. The expression of AcSDKP in human breast, colon, head and neck, kidney, lung, skin, ovary and prostate cancer tissues was shown to be greater than that in normal tissues.
AcSDKP and POP contribute to the malignant phenotype and these molecules are potentiel markers of cancer.
天然四肽乙酰 - 丝氨酸 - 天冬氨酸 - 赖氨酸 - 脯氨酸（AcSDKP）由胸腺素β4经脯氨酰寡肽酶（POP）裂解产生，是血管生成的生理刺激物。由于新血管形成在肿瘤发展中的关键作用，本研究检测了不同人类实体恶性肿瘤中AcSDKP的表达及POP的活性。
在人类血液样本、甲状腺肿和甲状腺乳头状癌组织标本以及商业癌症组织芯片中评估AcSDKP的表达和POP的活性。
在癌症患者中检测到肿瘤内血液中AcSDKP浓度显著升高，且组织中POP活性增强。研究表明，AcSDKP在人类乳腺癌、结肠癌、头颈癌、肾癌、肺癌、皮肤癌、卵巢癌和前列腺癌组织中的表达高于正常组织。
AcSDKP和POP促成恶性表型，这些分子可能是癌症的标志物。
