Synthesis and pharmacology of anti-inflammatory steroidal antedrugs.
作者信息
Khan M Omar F, Lee Henry J
机构信息
College of Pharmacy, Southwestern Oklahoma State University, 100 Campus Drive, Weatherford, Oklahoma 73096, USA.
出版信息
Chem Rev. 2008 Dec;108(12):5131-45. doi: 10.1021/cr068203e.
Abstract
摘要
相似文献
1
Synthesis and pharmacology of anti-inflammatory steroidal antedrugs.抗炎甾体前药的合成与药理学
Chem Rev. 2008 Dec;108(12):5131-45. doi: 10.1021/cr068203e.
2
New steroidal anti-inflammatory antedrugs: methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and methyl 21-acetyloxy-3,20-dioxo-11 beta, 17 alpha-dihydroxy-9 alpha-fluoro-1,4-pregnadiene-16 alpha-carboxylate.新型甾体抗炎前体药物：3,20 - 二氧代 - 9α - 氟 - 11β,17α,21 - 三羟基 - 1,4 - 孕二烯 - 16α - 羧酸甲酯和21 - 乙酰氧基 - 3,20 - 二氧代 - 11β,17α - 二羟基 - 9α - 氟 - 1,4 - 孕二烯 - 16α - 羧酸甲酯
Steroids. 1997 Jun;62(6):491-9. doi: 10.1016/s0039-128x(97)00020-2.
3
Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines.一些新型甾体[16α,17α - d]异恶唑啉的合成
Steroids. 2005 Jul;70(8):494-8. doi: 10.1016/j.steroids.2005.01.003. Epub 2005 Mar 20.
4
[Antedrugs and pro-antedrugs of corticosteroids].
Nihon Rinsho. 1994 Mar;52(3):691-7.
5
Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring.
J Med Chem. 2001 Feb 15;44(4):602-12. doi: 10.1021/jm001035c.
6
New steroidal anti-inflammatory antedrugs bind to macrophage glucocorticoid receptors and inhibit nitric oxide generation.
Steroids. 1998 Dec;63(12):644-9. doi: 10.1016/s0039-128x(98)00074-9.
7
Rare Chlorinated C Steroids Hocarnoids A and B from : Isolation, Semisynthesis, and Anti-inflammation.来自罕见的氯化C甾体类胡罗卜素A和B：分离、半合成及抗炎作用
J Org Chem. 2025 Apr 4;90(13):4714-4724. doi: 10.1021/acs.joc.5c00211. Epub 2025 Mar 20.
8
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
J Med Chem. 2001 Aug 30;44(18):2879-85. doi: 10.1021/jm010228c.
9
Synthesis of 6-(methoxycarbonyl)prednisolone and its derivatives as new antiinflammatory steroidal antedrugs.6-（甲氧基羰基）泼尼松龙及其衍生物作为新型抗炎甾体前药的合成
J Pharm Sci. 1994 Mar;83(3):357-61. doi: 10.1002/jps.2600830318.
10
Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor.新型糖皮质激素受体激动剂、部分激动剂及拮抗剂的合成
Bioorg Med Chem Lett. 2017 Jan 15;27(2):347-353. doi: 10.1016/j.bmcl.2016.11.007. Epub 2016 Nov 15.
引用本文的文献
1
Pharmacological Evaluation of Araliadiol as a Novel Anti-Inflammatory Agent in LPS-Induced RAW 264.7 Cells.刺囊酸作为新型抗炎剂在脂多糖诱导的RAW 264.7细胞中的药理学评价
Biomedicines. 2025 Jun 8;13(6):1408. doi: 10.3390/biomedicines13061408.
2
Glucocorticoids with or without fludrocortisone in septic shock: a narrative review from a biochemical and molecular perspective.糖皮质激素联合或不联合氟氢可的松治疗脓毒性休克：从生化和分子角度的叙述性综述。
Br J Anaesth. 2024 Jan;132(1):53-65. doi: 10.1016/j.bja.2023.10.034. Epub 2023 Nov 28.
3
The Evolution of Triamcinolone Acetonide Therapeutic Use in Retinal Diseases: From Off-Label Intravitreal Injection to Advanced Nano-Drug Delivery Systems.曲安奈德在视网膜疾病治疗应用中的演变：从非标签玻璃体腔内注射到先进的纳米药物递送系统。
Biomedicines. 2023 Jul 5;11(7):1901. doi: 10.3390/biomedicines11071901.
4
A Comprehensive Review on Steroidal Bioconjugates as Promising Leads in Drug Discovery.甾体生物共轭物作为药物发现中有前景的先导化合物的综合综述。
ACS Bio Med Chem Au. 2022 Mar 23;2(4):340-369. doi: 10.1021/acsbiomedchemau.1c00071. eCollection 2022 Aug 17.
5
Structure, Mutagenesis, and QM:MM Modeling of 3-Ketosteroid Δ-Dehydrogenase from ─The Role of a New Putative Membrane-Associated Domain and Proton-Relay System in Catalysis.结构、诱变和 QM:MM 建模的 3-酮甾体 Δ-脱氢酶——新的假定膜相关结构域和质子传递系统在催化中的作用。
Biochemistry. 2023 Feb 7;62(3):808-823. doi: 10.1021/acs.biochem.2c00576. Epub 2023 Jan 10.
6
Identification and Development of Therapeutics for COVID-19.新型冠状病毒肺炎治疗方法的识别与开发
mSystems. 2021 Dec 21;6(6):e0023321. doi: 10.1128/mSystems.00233-21. Epub 2021 Nov 2.
7
Recent Advances in the Synthesis of Ibuprofen and Naproxen.布洛芬和萘普生的合成新进展。
Molecules. 2021 Aug 7;26(16):4792. doi: 10.3390/molecules26164792.
8
Identification and Development of Therapeutics for COVID-19.新型冠状病毒肺炎治疗方法的识别与开发
ArXiv. 2021 Mar 3:arXiv:2103.02723v3.
9
Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models.雾化吸入MIDD0301可降低中重度小鼠哮喘模型的气道高反应性。
ACS Pharmacol Transl Sci. 2020 Dec 2;3(6):1381-1390. doi: 10.1021/acsptsci.0c00180. eCollection 2020 Dec 11.
10
Novel d-Annulated Pentacyclic Steroids: Regioselective Synthesis and Biological Evaluation in Breast Cancer Cells.新型 d-稠合五环甾类化合物的区域选择性合成及其在乳腺癌细胞中的生物学评价。
Molecules. 2020 Jul 31;25(15):3499. doi: 10.3390/molecules25153499.
本文引用的文献
1
Loteprednol etabonate: clinical potential in the management of ocular inflammation.卤替泼诺酯：在眼部炎症治疗中的临床潜力。
BioDrugs. 1998 Oct;10(4):329-39. doi: 10.2165/00063030-199810040-00007.
2
In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone.新型甾体前药的体外抗炎活性：泼尼松龙和9α-氟泼尼松龙的[16α,17α-d]异恶唑啉及[16α,17α-d]-3'-羟基-亚氨基甲酰基异恶唑啉衍生物
Steroids. 2006 Mar;71(3):183-8. doi: 10.1016/j.steroids.2005.10.003. Epub 2005 Nov 23.
3
Antedrugs: an approach to safer drugs.
Curr Med Chem. 2005;12(19):2227-39. doi: 10.2174/0929867054864840.
4
The search for safer glucocorticoid receptor ligands.寻找更安全的糖皮质激素受体配体。
Endocr Rev. 2005 May;26(3):452-64. doi: 10.1210/er.2005-0002. Epub 2005 Apr 6.
5
Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma.
J Med Chem. 2005 Mar 24;48(6):2167-75. doi: 10.1021/jm049479m.
6
Chirality effect of C-20 on metabolism of methyl 11beta,17alpha,20-trihydroxy-3-oxo-1,4-pregnadien-21-oate derivatives.C-20的手性对11β,17α,20-三羟基-3-氧代-1,4-孕甾二烯-21-酸甲酯衍生物代谢的影响
Steroids. 2004 Feb;69(2):87-91. doi: 10.1016/j.steroids.2003.10.002.
7
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
8
[On the mechanism of cortisone inhibition of connective tissue proliferation].[关于可的松抑制结缔组织增生的机制]
Experientia. 1950 Dec 15;6(12):469-71. doi: 10.1007/BF02154110.
9
COMPARATIVE EFFICACY OF TOPICAL ANTI-INFLAMMATORY CORTICOSTEROIDS.
J Pharm Sci. 1965 Mar;54:335-54. doi: 10.1002/jps.2600540302.
10
6-ALPHA-FLUORO- AND 6-ALPHA-METHYL-16-ALPHA-FLUOPROREDNISOLONES.
J Med Chem. 1964 Nov;7:748-51. doi: 10.1021/jm00336a015.
Zotero 插件