血管内皮细胞衰老：从机制到病理生理学
Vascular endothelial senescence: from mechanisms to pathophysiology.
作者信息
Erusalimsky Jorge D
机构信息
Cardiff School of Health Sciences, University of Wales Institute, Cardiff CF5 2YB, UK.
出版信息
J Appl Physiol (1985). 2009 Jan;106(1):326-32. doi: 10.1152/japplphysiol.91353.2008. Epub 2008 Nov 26.
Abstract
Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence in the vascular endothelium. I will also discuss the mechanisms and factors that modulate endothelial cell replicative capacity and the onset of senescence. Finally, I will examine the senescent phenotype and its possible consequences for the development and progression of vascular diseases.
摘要
大多数具有有丝分裂能力的哺乳动物细胞类型能够通过经历一种表型独特且永久的生长停滞形式，即“细胞衰老”，来应对压力。这种反应在细胞培养中已得到广泛研究，最近还发现它在体内的许多组织中也会发生。在这篇综述中，我将阐述血管内皮细胞中发生衰老的情况。我还将讨论调节内皮细胞复制能力和衰老起始的机制及因素。最后，我将研究衰老表型及其对血管疾病发生和发展可能产生的影响。
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