Verma S C, McNeill J H
J Pharmacol Exp Ther. 1977 Feb;200(2):352-62.
Histamine can stiumulate the heart by directly interacting with cardiac histamine receptors. In the present study we have investigated the cardiac effects of histamine, 4-methylhistamine (a specific H2-receptor agonist) and 2-pyridylethylamine PEA, a specific H1-receptor agonist] on spontaneously beating right atria and electrically driven left atria and right ventricle strips of the guinea pig. Left atria were driven at 1 Hz and right ventricle strips at 2.5 Hz and at twice the threshold voltage. Histamine and PEA produced a dose-dependent positive inotropic effect on the left atria. The dose-response curves were shifted to the right in a parallel fashion by promethazine (3 x 10(-6)M)+... Burimamide did not affect either dose-response curve. Histamine and 4-methylhistamine had a positive chromnotropic effect on right atria and a positive inotropic effect on right ventricle strips.
组胺可通过与心脏组胺受体直接相互作用来刺激心脏。在本研究中，我们研究了组胺、4-甲基组胺（一种特异性H2受体激动剂）和2-吡啶乙胺（PEA，一种特异性H1受体激动剂）对豚鼠自发性搏动的右心房以及电驱动的左心房和右心室肌条的心脏效应。左心房以1Hz的频率驱动，右心室肌条以2.5Hz的频率且在两倍阈电压下驱动。组胺和PEA对左心房产生剂量依赖性正性肌力作用。异丙嗪（3×10⁻⁶M）使剂量-反应曲线以平行方式右移……布立马胺对两条剂量-反应曲线均无影响。组胺和4-甲基组胺对右心房有正性变时作用，对右心室肌条有正性肌力作用。
