Nakashima S, Sugimoto H, Inoue M, Karashima S, Onitsuka T, Koga Y
Second Department of Surgery, Miyazaki Medical College, Japan.
Nihon Geka Gakkai Zasshi. 1991 Feb;92(2):206-13.
This study compared the growth of vascular anastomoses performed with either polypropylene or polydioxanone sutures and with either continuous running suture or interrupted suture technique. Primary end-to-end anastomoses of the infrarenal aorta were performed in 38 puppies. Nineteen were performed with 5-0 polypropylene sutures; in ten all sutures were placed in continuous fashion, and in nine in interrupted fashion. The other nineteen were performed with 5-0 polydioxanone sutures; in ten the sutures were placed in continuous fashion, and in nine in interrupted fashion. The animals were subjected to the repeated aortograms at 2, 4, 8 weeks, 6 months and 1 year following operation. Each abdominal aorta was subjected to burst test, and pathological examination. All anastomoses were patent and tolerated burst-test (300 mmHg). Neither aneurysm nor dilatation of anastomotic site was observed. Anastomotic area was significantly smaller and more stenotic in the continuous polypropylene suture group than in other three groups at 8 weeks, 6 months and 1 year following operation. There was no significant difference among these three groups. No suture materials were observed in the polydioxanone suture groups after 6 months following operation. This study suggests that polydioxanone suture will be useful for the repair of cardiovascular anomalies where growth of the suture line is required.
本研究比较了使用聚丙烯或聚二氧六环酮缝线以及连续缝合或间断缝合技术进行的血管吻合口的生长情况。对38只幼犬进行了肾下腹主动脉的端端吻合术。19例使用5-0聚丙烯缝线进行；其中10例所有缝线采用连续缝合方式，9例采用间断缝合方式。另外19例使用5-0聚二氧六环酮缝线进行；其中10例缝线采用连续缝合方式，9例采用间断缝合方式。在术后2周、4周、8周、6个月和1年对动物进行重复主动脉造影。对每条腹主动脉进行破裂试验和病理检查。所有吻合口均通畅且耐受破裂试验（300 mmHg）。未观察到吻合部位有动脉瘤或扩张。在术后8周、6个月和1年时，连续聚丙烯缝合组的吻合口面积明显小于其他三组，且更狭窄。这三组之间无显著差异。术后6个月后，聚二氧六环酮缝线组未观察到缝线材料。本研究表明，聚二氧六环酮缝线将有助于修复需要缝线部位生长的心血管畸形。
