半胱氨酸-3对中枢胆碱能突触的双重作用。
Dual effects of hemicholinium-3 at central cholinergic synapses.
作者信息
Craig C R, Curtis D R, Lodge D
出版信息
J Physiol. 1977 Jan;264(2):367-77. doi: 10.1113/jphysiol.1977.sp011673.
Abstract
- Hemicholinium-3 (HC-3) has at least two presynaptic effects at cholinergic synapses between motor acon collaterals and spinal Renshaw cells, neither of which influenced non-cholinergic excitatory synapses on dorsal horn interneurones. 2. One, which occurred independently of repetitive activity of the synapses and which resulted in increased latency of synaptic excitation, presumably involved changes in the properties of presynaptic fibres and terminals which influenced transmitter release. 3. The other, which depended on continuous repetitive synaptic activity, was consistent with depletion by HC-3 of presynaptic stores of acetylcholine (ACh).
摘要
- 半胱氨酸-3（HC-3）在运动轴突侧支与脊髓闰绍细胞之间的胆碱能突触处至少有两种突触前效应，这两种效应均不影响背角中间神经元上的非胆碱能兴奋性突触。2. 其中一种效应独立于突触的重复活动而发生，导致突触兴奋潜伏期延长，推测这涉及影响递质释放的突触前纤维和终末特性的改变。3. 另一种效应依赖于持续的重复突触活动，这与HC-3耗尽突触前乙酰胆碱（ACh）储备的情况一致。
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