Gershtein E S, Korotkova E A, Prorokov V V, Kushlinsky N E
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2008 Mar;145(3):362-6. doi: 10.1007/s10517-008-0092-8.
Enzyme immunoassay studies revealed increased content of matrix metalloproteinases 2, 3 and 13 in tumors compared to the adjacent histologically unchanged mucosa in 70-90% patients with colorectal cancer, while the increase in the content of type 2 metalloproteinase tissue inhibitor did not reach the level of statistic significance. Plasma concentrations of these proteins did not correlate with the corresponding values in the tumors and did not surpass the normal levels, while their decrease after removal of the primary tumor was observed only in patients with initially high levels of this parameter.
酶免疫分析研究显示，在70%-90%的结直肠癌患者中，与相邻组织学上未改变的黏膜相比，肿瘤中基质金属蛋白酶2、3和13的含量增加，而2型金属蛋白酶组织抑制剂含量的增加未达到统计学显著水平。这些蛋白质的血浆浓度与肿瘤中的相应值不相关，且未超过正常水平，而仅在该参数初始水平较高的患者中观察到原发肿瘤切除后其浓度下降。
