Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.
作者信息
Gupta S V, Greenfield N J, Poe M, Makulu D R, Williams M N, Moroson B A, Bertino J R
出版信息
Biochemistry. 1977 Jul 12;16(14):3073-9. doi: 10.1021/bi00633a005.
PMID:19040
Abstract
摘要
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Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.来自L1210淋巴瘤耐药亚系的二氢叶酸还原酶。通过亲和层析法进行纯化以及紫外差示分光光度法和圆二色性研究。
Biochemistry. 1977 Jul 12;16(14):3073-9. doi: 10.1021/bi00633a005.
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Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells.来自氨甲蝶呤抗性L1210细胞的二氢叶酸还原酶的底物和抑制剂复合物
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Improved purification of tetrahydrofolate dehydrogenase from L1210 leukemia by affinity chromatography.通过亲和色谱法改进从L1210白血病细胞中纯化四氢叶酸脱氢酶的方法。
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Purification of tetrahydrofolate dehydrogenase by affinity chromatography.通过亲和色谱法纯化四氢叶酸脱氢酶。
Biochim Biophys Acta. 1972 Apr 7;268(1):35-40. doi: 10.1016/0005-2744(72)90194-5.
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Immunologic heterogeneity of dihydrofolate reductase from methotrexate sensitive and resistant L1210 leukemia cells.来自甲氨蝶呤敏感和耐药L1210白血病细胞的二氢叶酸还原酶的免疫异质性。
Proc Soc Exp Biol Med. 1985 Oct;180(1):98-102. doi: 10.3181/00379727-180-42149.
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Multiple forms of L1210 dihydrofolate reductase differing in affinity for methotrexate.对甲氨蝶呤亲和力不同的多种形式的L1210二氢叶酸还原酶。
Biochem Biophys Res Commun. 1984 Feb 29;119(1):352-8. doi: 10.1016/0006-291x(84)91658-9.
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Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification and properties.
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Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.来自抗甲氨蝶呤大肠杆菌菌株的二氢叶酸还原酶的圆二色性研究。
Biochemistry. 1972 Dec 5;11(25):4706-11. doi: 10.1021/bi00775a011.
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Dihydrofolate reductase activity and loss of resistance in an antifolate-resistant subline of leukemia L1210 after discontinuation of treatment.白血病L1210抗叶酸耐药亚系在停药后二氢叶酸还原酶活性及耐药性丧失
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Folate antagonists covalently linked to carbohydrates: synthesis, properties, and use in the purification of dihydrofolate reductases.与碳水化合物共价连接的叶酸拮抗剂：合成、性质及其在二氢叶酸还原酶纯化中的应用
Arch Biochem Biophys. 1972 May;150(1):15-22. doi: 10.1016/0003-9861(72)90004-5.
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Interaction of methotrexate, folates, and pyridine nucleotides with dihydrofolate reductase: calorimetric and spectroscopic binding studies.甲氨蝶呤、叶酸和吡啶核苷酸与二氢叶酸还原酶的相互作用：量热法和光谱结合研究。
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