Mayers I, Johnson D, Wobeser W, To T
Department of Anaesthesia, Royal University Hospital, University of Saskatchewan, Saskatoon.
Clin Invest Med. 1991 Feb;14(1):44-54.
We indirectly examined the role of prostaglandins and leukotrienes in modulation of hypoxic pulmonary vasoconstriction. We used a cyclo-oxygenase inhibitor (indomethacin) and a lipoxygenase inhibitor (diethylcarbamazine) in an in-situ canine lung lobe preparation. We measured total resistance in two control groups ventilated with either 35% O2 or 3% O2 (groups CC and HC respectively). Two additional groups treated with indomethacin (groups CI and HI), and two groups treated with the combination of indomethacin and diethylcarbamazine (groups CID and HID), were also ventilated with either 35% O2 or 3% O2 respectively. Total resistance was significantly greater in hypoxic groups compared with their respective control oxygen groups. Total resistance was greatest in group HI (0.288 +/- 0.103 cm H2O.ml-1 min-1), intermediate in group HID (0.153 +/- 0.016 cm H2O.ml-1 min-1) and lowest in group HC (0.066 +/- 0.017 cm H2O.ml-1 min-1). We concluded that cyclo-oxygenase blockade augments hypoxic pulmonary vasoconstriction by decreasing production of a vasodilating prostaglandin. Hypoxia also increases production of a vasoconstricting leukotriene in the presence of cyclo-oxygenase blockade with indomethacin.
我们间接研究了前列腺素和白三烯在调节低氧性肺血管收缩中的作用。我们在犬原位肺叶制备实验中使用了一种环氧化酶抑制剂（吲哚美辛）和一种脂氧化酶抑制剂（乙胺嗪）。我们测量了分别用35%氧气或3%氧气通气的两个对照组（分别为CC组和HC组）的总阻力。另外两组用吲哚美辛处理（CI组和HI组），以及两组用吲哚美辛和乙胺嗪联合处理（CID组和HID组），也分别用35%氧气或3%氧气通气。与各自的对照氧组相比，低氧组的总阻力显著更高。总阻力在HI组最大（0.288±0.103厘米水柱·毫升⁻¹·分钟⁻¹），在HID组居中（0.153±0.016厘米水柱·毫升⁻¹·分钟⁻¹），在HC组最低（0.066±0.017厘米水柱·毫升⁻¹·分钟⁻¹）。我们得出结论，环氧化酶阻断通过减少血管舒张性前列腺素的产生增强低氧性肺血管收缩。在使用吲哚美辛阻断环氧化酶的情况下，低氧还会增加血管收缩性白三烯的产生。
