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从神经节苷脂沉积症患者尿液中的GM1分离出的与N-糖基化蛋白聚糖相关的一种新型链终止剂Galβ1-6Galβ1-4）GlcNAc的表征。

Characterization of a novel type of chain-terminator Gal beta 1-6Gal beta 1-4)GlcNAc in an oligosaccharide related to N-glycosylated protein glycans isolated from GM1 the urine of patients with gangliosidosis.

作者信息

Michalski J C, Lemoine J, Wieruszeski J M, Fournet B, Montreuil J, Strecker G

机构信息

Laboratoire de Chimie Biologique, Unité Mixte de Recherche, Université des Sciences et Techniques de Lille Flandres-Artois, France.

出版信息

Eur J Biochem. 1991 Jun 1;198(2):521-6. doi: 10.1111/j.1432-1033.1991.tb16045.x.

DOI:10.1111/j.1432-1033.1991.tb16045.x
PMID:1904026
Abstract

Two new oligosaccharides were isolated from the urine of a patient with GM1 gangliosidosis. Final purification of the oligosaccharides was accomplished by capillary supercritical fluid chromatography. Structural analysis was by chemical analysis, chemical-ionization mass spectrometry and 400-MHz 1H-NMR spectroscopy, leading to two primary structures. The first is derived from a classical triantennary N-acetyllactosamine-type glycan: Gal beta 1-4GlcNAc beta 1-4(Gal beta 1-4GlcNAc beta 1-2)Man alpha 1-3Man beta 1-4GlcNAc. The second is unusual with a terminal disaccharide Gal beta 1-6Gal, which had not yet been described for glycans of the N-acetyllactosamine type: Gal beta 1-6Gal beta 1-4GlcNAc beta 1-2Man alpha 1-6Man beta 1-4GlcNAc.

摘要

从一名患有GM1神经节苷脂贮积症患者的尿液中分离出两种新的寡糖。寡糖的最终纯化通过毛细管超临界流体色谱法完成。结构分析采用化学分析、化学电离质谱和400兆赫兹1H-NMR光谱法，得出两种主要结构。第一种结构源自经典的三触角N-乙酰乳糖胺型聚糖：Galβ1-4GlcNAcβ1-4（Galβ1-4GlcNAcβ1-2）Manα1-3Manβ1-4GlcNAc。第二种结构不同寻常，具有末端二糖Galβ1-6Gal，这种结构在N-乙酰乳糖胺型聚糖中尚未见报道：Galβ1-6Galβ1-4GlcNAcβ1-2Manα1-6Manβ1-4GlcNAc。

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Characterization of a novel type of chain-terminator Gal beta 1-6Gal beta 1-4)GlcNAc in an oligosaccharide related to N-glycosylated protein glycans isolated from GM1 the urine of patients with gangliosidosis.从神经节苷脂沉积症患者尿液中的GM1分离出的与N-糖基化蛋白聚糖相关的一种新型链终止剂Galβ1-6Galβ1-4）GlcNAc的表征。
Eur J Biochem. 1991 Jun 1;198(2):521-6. doi: 10.1111/j.1432-1033.1991.tb16045.x.
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