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一种雌激素依赖性多聚核糖体蛋白与鸡卵黄蛋白原mRNA的5'非翻译区结合。

An estrogen-dependent polysomal protein binds to the 5' untranslated region of the chicken vitellogenin mRNA.

作者信息

Liang H M, Jost J P

机构信息

Friedrich-Miescher Institute, Basel, Switzerland.

出版信息

Nucleic Acids Res. 1991 May 11;19(9):2289-94. doi: 10.1093/nar/19.9.2289.

DOI:10.1093/nar/19.9.2289
PMID:1904152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC329432/
Abstract

An estrogen-dependent protein present in chicken liver polysomes binds to the 5' untranslated region of the chicken vitellogenin II mRNA. Competition binding assays with different RNAs indicate that the binding of the polysomal protein to this region is sequence specific. Of the tissues tested, this RNA binding activity is liver specific. In vivo kinetics of appearance of the binding activity following a single injection of estrogen to immature chicks are similar to the rate of accumulation of vitellogenin mRNA. The molecular weight of the polysomal protein has been estimated to be 66,000 on the basis of UV crosslinking and subsequent SDS polyacrylamide gel electrophoresis. In vitro RNA decay assays carried out with a minivitellogenin mRNA suggest that the estrogen-dependent polysomal protein may be involved in the estrogen-mediated stabilization of the chicken vitellogenin II mRNA.

摘要

鸡肝多核糖体中存在的一种雌激素依赖性蛋白与鸡卵黄生成素II mRNA的5'非翻译区结合。用不同RNA进行的竞争结合试验表明，多核糖体蛋白与该区域的结合具有序列特异性。在所测试的组织中，这种RNA结合活性具有肝脏特异性。对未成熟雏鸡单次注射雌激素后，结合活性出现的体内动力学与卵黄生成素mRNA的积累速率相似。根据紫外线交联及随后的SDS聚丙烯酰胺凝胶电泳，多核糖体蛋白的分子量估计为66,000。用微型卵黄生成素mRNA进行的体外RNA衰变试验表明，雌激素依赖性多核糖体蛋白可能参与了雌激素介导的鸡卵黄生成素II mRNA的稳定过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/7a4b72d90b5a/nar00089-0051-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/96f8864db3f7/nar00089-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/05dc1fb49f8b/nar00089-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/4ba77f117288/nar00089-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/b14e3f6a6c4e/nar00089-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/755959da7373/nar00089-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/7a4b72d90b5a/nar00089-0051-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/96f8864db3f7/nar00089-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/05dc1fb49f8b/nar00089-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/4ba77f117288/nar00089-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/b14e3f6a6c4e/nar00089-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/755959da7373/nar00089-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afd8/329432/7a4b72d90b5a/nar00089-0051-b.jpg

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Monoclonal antibodies against estrogen receptor: interaction with different molecular forms and functions of the receptor.抗雌激素受体单克隆抗体：与受体不同分子形式及功能的相互作用
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A novel transforming growth factor-beta 1 responsive cytoplasmic trans-acting factor binds selectively to the 3'-untranslated region of mammalian ribonucleotide reductase R2 mRNA: role in message stability.一种新型的转化生长因子-β1 反应性细胞质反式作用因子选择性地结合到哺乳动物核糖核苷酸还原酶 R2 mRNA 的 3' 非翻译区：在信使稳定性中的作用。
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