来自嗜热栖热菌的蛋白质CTC拥有一个完整大小的5S核糖体RNA结合结构域。

Protein CTC from Aquifex aeolicus possesses a full-sized 5S rRNA-binding domain.

作者信息

Korobeinikova A V, Shestakov S A, Korepanov A P, Garber M B, Gongadze G M

机构信息

Institute of Protein Research, Russian Academy of Sciences, Institutskaya 4, 142290 Pushchino, Moscow Region, Russian Federation.

出版信息

Biochimie. 2009 Mar;91(3):453-6. doi: 10.1016/j.biochi.2008.11.001. Epub 2008 Nov 17.

DOI:10.1016/j.biochi.2008.11.001

PMID:19041925

Abstract

Ribosomal 5S RNA is the only identified target for proteins of the CTC family. All known proteins of this family, except for CTC from Aquifex aeolicus, contain a full-sized 5S rRNA-binding domain. In the present study a mistake in the published A. aeolicus genome is corrected. It has been demonstrated that the ctc gene of this organism encodes the protein with a full-length 5S rRNA-binding domain. This protein binds specifically to the bacterial 5S rRNA. Thereby, our data show that CTC A. aeolicus is not an exception from the other known CTC proteins.

摘要

核糖体5S RNA是已确定的唯一与CTC家族蛋白结合的靶点。该家族所有已知蛋白，除嗜热栖热菌的CTC外，均含有一个完整大小的5S rRNA结合结构域。在本研究中，已修正已发表的嗜热栖热菌基因组中的一个错误。已证明该生物体的ctc基因编码的蛋白具有全长5S rRNA结合结构域。该蛋白能特异性结合细菌5S rRNA。因此，我们的数据表明嗜热栖热菌的CTC并非其他已知CTC蛋白中的例外。