Freiberg A A, Cantor R, Freiberg R A
Department of Orthopaedic Surgery, University of Cincinnati College of Medicine, Ohio.
Clin Orthop Relat Res. 1991 Jun(267):93-6.
The reported incidence of heterotopic ossification (HO) after total hip arthroplasty (THA) ranges up to 50%. HO causes pain and restricted range of motion (ROM) in a significant number of these THA patients. From 1983 to 1988, 177 primary cemented THAs were performed in 131 consecutive patients. Six hundred fifty milligrams of buffered aspirin administered twice daily for two weeks was used as a prophylaxis for thromboembolic disease. There was an unusually low incidence of HO in this group of patients. Aspirin treatment was instituted the night before surgery and continued for two weeks, except in 13 patients (7%) who had to stop treatment because of gastrointestinal symptoms. All patients had at least one year of roentgenographic study postoperatively. According to the Brooker Classification of HO, there were 169 (96%) Grade I and Grade 0 hips, six (3%) Grade II, two (1%) Grade III, and no Grade IV. None of the patients had symptomatic restriction of ROM attributable to heterotopic bone. Aspirin is a safe and inexpensive agent for prevention of HO after THA.
据报道，全髋关节置换术（THA）后异位骨化（HO）的发生率高达50%。在大量接受THA手术的患者中，HO会导致疼痛和活动范围（ROM）受限。1983年至1988年，对131例连续患者进行了177例初次骨水泥型THA手术。每天两次服用650毫克缓冲阿司匹林，持续两周，作为预防血栓栓塞性疾病的措施。该组患者中HO的发生率异常低。阿司匹林治疗在手术前一晚开始，持续两周，但有13例患者（7%）因胃肠道症状不得不停止治疗。所有患者术后至少进行了一年的X线检查。根据布鲁克（Brooker）HO分类法，有169例（96%）髋关节为I级和0级，6例（3%）为II级，2例（1%）为III级，无IV级。没有患者因异位骨导致有症状的ROM受限。阿司匹林是预防THA后HO的一种安全且廉价的药物。
