法属波利尼西亚分化型甲状腺癌的人体测量学因素：一项病例对照研究。

Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case-control study.

作者信息

Brindel Pauline, Doyon Françoise, Rachédi Frédérique, Boissin Jean-Louis, Sebbag Joseph, Shan Larrys, Chungue Vaiana, Bost-Bezeaud Frédérique, Petitdidier Patrice, Paoaafaite John, Teuri Joseph, de Vathaire Florent

机构信息

INSERM Unit 605, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

出版信息

Cancer Causes Control. 2009 Jul;20(5):581-90. doi: 10.1007/s10552-008-9266-y. Epub 2008 Nov 30.

DOI:10.1007/s10552-008-9266-y

PMID:19043789

Abstract

OBJECTIVES

French Polynesia has one of the world's highest thyroid cancer incidence rates. A case-control study among native residents of French Polynesia included 219 cases of differentiated thyroid cancers diagnosed between 1979 and 2004 (195 women/24 men) matched with 359 population controls (315 women/44 men) on the date of birth.

METHODS

Anthropometric factors were analyzed by conditional logistic regression.

RESULTS

The risk of thyroid cancer for women in the highest quartile of body mass index (BMI) before diagnosis and at age 18 was 2.3-fold higher (95% CI, 1.1-4.7 p = 0.04) and 2.3-fold higher (95% CI, 1.2-4.4 p < 0.01), respectively, compared with the lowest. Women who were overweight (BMI = 25-29.9 kg/m2) or obese (BMI > or = 30 kg/m2) at age 18 and before diagnosis had an increased risk compared with those with a normal lifelong weight (OR = 6.2; 95% CI, 2.5-15.5 p < 0.01). Results for excess weight appeared in similar directions for men, although the number of cases was too small to provide reliable estimates. Height was positively associated with thyroid cancer among men and women.

CONCLUSION

This study shows the role of excess body weight, especially if the onset is during early adulthood, and elevated height in the risk of differentiated thyroid cancer in populations born in French Polynesia.

摘要

目的

法属波利尼西亚是世界上甲状腺癌发病率最高的地区之一。一项针对法属波利尼西亚当地居民的病例对照研究纳入了1979年至2004年间确诊的219例分化型甲状腺癌病例（195名女性/24名男性），并按出生日期与359名人群对照（315名女性/44名男性）进行匹配。

方法

通过条件逻辑回归分析人体测量因素。

结果

诊断前和18岁时体重指数（BMI）处于最高四分位数的女性患甲状腺癌的风险分别比最低四分位数的女性高2.3倍（95%CI，1.1 - 4.7；p = 0.04）和2.3倍（95%CI，1.2 - 4.4；p < 0.01）。18岁时及诊断前超重（BMI = 25 - 29.9 kg/m²）或肥胖（BMI≥30 kg/m²）的女性与体重正常的女性相比，患病风险增加（OR = 6.2；95%CI，2.5 - 15.5；p < 0.01）。男性的超重结果也呈现类似趋势，尽管病例数量过少无法提供可靠估计。身高与男性和女性的甲状腺癌呈正相关。