一项基于人群的病例对照研究（美国）中人体测量学指标与卵巢癌风险的关系

Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States).

作者信息

Peterson Neeraja B, Trentham-Dietz Amy, Newcomb Polly A, Chen Zhi, Gebretsadik Tebeb, Hampton John M, Stampfer Meir J, Willett Walter C, Egan Kathleen M

机构信息

Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232-8300, USA.

出版信息

Cancer Causes Control. 2006 May;17(4):459-67. doi: 10.1007/s10552-005-0416-1.

DOI:10.1007/s10552-005-0416-1

PMID:16596298

Abstract

OBJECTIVE

To examine the relationship between anthropometric measures and ovarian cancer by menopausal status.

METHODS

We analyzed data from a population-based case-control study comprised of 700 incident cases of epithelial ovarian cancer and 5,943 population controls from Massachusetts and Wisconsin enrolled between 1993 and 2001. In a telephone interview, information was gathered on established ovarian cancer risk factors, as well as adult height and age-specific body weight. Logistic regression was used to estimate multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for body mass index (BMI) throughout life.

RESULTS

Recent BMI had no significant association with ovarian cancer risk (P-trend 0.14 for continuous BMI), after adjustment for age and other ovarian cancer risk factors. However, a non-significant positive association (overall P-trend 0.08) was observed for BMI at age 20; the risk estimate comparing a body mass of >25 kg/m2 to the lowest quintile (<or=18.88 kg/m2) was moderately but non-significantly elevated (OR 1.46; 95% CI 0.92, 2.31).

CONCLUSION

Results of this study suggest that maintenance of a lean body mass, particularly in early adult life, may decrease ovarian cancer risk.

摘要

目的

按绝经状态研究人体测量指标与卵巢癌之间的关系。

方法

我们分析了一项基于人群的病例对照研究的数据，该研究包括1993年至2001年间在马萨诸塞州和威斯康星州招募的700例上皮性卵巢癌新发病例和5943名人群对照。在电话访谈中，收集了既定的卵巢癌危险因素以及成人身高和特定年龄的体重信息。采用逻辑回归估计一生中体重指数（BMI）的多变量调整比值比（OR）和95%置信区间（CI）。

结果

在调整年龄和其他卵巢癌危险因素后，近期BMI与卵巢癌风险无显著关联（连续BMI的P趋势为0.14）。然而，20岁时的BMI观察到非显著的正相关（总体P趋势为0.08）；将体重>25 kg/m²与最低五分位数（≤18.88 kg/m²）进行比较的风险估计值适度但不显著升高（OR 1.46；95% CI 0.92，2.31）。