使用Cu(OTf)₂催化的炔丙基化/环异构化串联反应一锅法合成取代呋喃。
One-pot synthesis of substituted furans using Cu(OTf)(2)-catalyzed propargylation/cycloisomerization tandem reaction.
作者信息
Pan Ying-ming, Zhao Su-yan, Ji Wen-hua, Zhan Zhuang-ping
机构信息
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China.
出版信息
J Comb Chem. 2009 Jan-Feb;11(1):103-9. doi: 10.1021/cc8001316.
PMID:19046075
Abstract
A convenient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted furans derivatives from 1,3-dicarbonyl compounds and enoxysilanes with propargylic alcohols or acetates using copper(II) triflate as a bifunctional catalyst. This method provides a flexible and rapid route to substituted furans.
摘要
已开发出一种便捷的一锅法炔丙基化/环异构化串联反应，以三氟甲磺酸铜（II）作为双功能催化剂，由1,3 - 二羰基化合物、烯氧基硅烷与炔丙醇或乙酸酯合成取代呋喃衍生物。该方法为合成取代呋喃提供了一条灵活且快速的途径。
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