猛禽直击新陈代谢。
Raptor swoops in on metabolism.
作者信息
Shaw Reuben J
机构信息
Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
出版信息
Cell Metab. 2008 Nov;8(5):343-4. doi: 10.1016/j.cmet.2008.10.007.
PMID:19046565
Abstract
The mammalian target of rapamycin (mTOR) serine/threonine kinase plays a central role in insulin signaling and cell growth, through two distinct complexes with its subunits raptor or rictor. In this issue, two reports utilizing tissue-specific knockout mice detail key roles for mTORC1 in skeletal muscle and adipose tissue function.
摘要
雷帕霉素哺乳动物靶点（mTOR）丝氨酸/苏氨酸激酶通过与其亚基raptor或rictor形成的两种不同复合物，在胰岛素信号传导和细胞生长中发挥核心作用。在本期中，两篇利用组织特异性敲除小鼠的报告详细阐述了mTORC1在骨骼肌和脂肪组织功能中的关键作用。
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