越南受试者中双氢青蒿素和哌喹两种固定剂量片剂剂型的药代动力学和生物等效性评价。
Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects.
作者信息
Chinh Nguyen Trong, Quang Nguyen Ngoc, Thanh Nguyen Xuan, Dai Bui, Geue Jason P, Addison Russell S, Travers Thomas, Edstein Michael D
机构信息
Department of Infectious Diseases, Military Hospital, Hanoi, Vietnam.
出版信息
Antimicrob Agents Chemother. 2009 Feb;53(2):828-31. doi: 10.1128/AAC.00927-08. Epub 2008 Dec 1.
Abstract
The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.
摘要
在健康的越南受试者中，发现双氢青蒿素和哌喹的两种固定剂量组合（Artekin和Arterakine）生物不等效。然而，由于两种制剂之间双氢青蒿素和哌喹的血浆峰浓度和浓度-时间曲线下面积仅略有差异，预计在治疗疟疾感染时具有相似的治疗效果。
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