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本文引用的文献

1
Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects.抗疟药物哌喹在健康越南受试者中的药代动力学。
Am J Trop Med Hyg. 2008 Oct;79(4):620-3.
2
The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.食物对越南健康志愿者体内磷酸哌喹药代动力学的影响。
Acta Trop. 2008 Aug;107(2):145-9. doi: 10.1016/j.actatropica.2008.05.013. Epub 2008 May 24.
3
Safety, tolerability, and single- and multiple-dose pharmacokinetics of piperaquine phosphate in healthy subjects.磷酸哌喹在健康受试者中的安全性、耐受性以及单剂量和多剂量药代动力学
J Clin Pharmacol. 2008 Feb;48(2):166-75. doi: 10.1177/0091270007310384.
4
Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.在泰国恶性疟原虫疟疾患者中，采用双氢青蒿素-哌喹两种不同治疗方案后哌喹的群体药代动力学。
Antimicrob Agents Chemother. 2008 Mar;52(3):1052-61. doi: 10.1128/AAC.00955-07. Epub 2008 Jan 7.
5
Artemisinin-based combination treatment of falciparum malaria.基于青蒿素的恶性疟原虫疟疾联合治疗。
Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):181-92.
6
Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria.磷酸哌喹和氯喹在美拉尼西亚单纯性疟疾儿童中的药代动力学及疗效
Antimicrob Agents Chemother. 2008 Jan;52(1):237-43. doi: 10.1128/AAC.00555-07. Epub 2007 Oct 29.
7
Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison.用于印度尼西亚巴布亚地区抗药性恶性疟和间日疟的两种固定剂量青蒿素联合疗法：一项开放标签随机对照研究
Lancet. 2007 Mar 3;369(9563):757-765. doi: 10.1016/S0140-6736(07)60160-3.
8
Malaria--time to act.疟疾——是采取行动的时候了。
N Engl J Med. 2006 Nov 9;355(19):1956-7. doi: 10.1056/NEJMp068214.
9
Pitfalls in estimating piperaquine elimination.估算哌喹消除过程中的陷阱。
Antimicrob Agents Chemother. 2005 Dec;49(12):5127-8. doi: 10.1128/AAC.49.12.5127-5128.2005.
10
A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.一项关于双氢青蒿素-哌喹简单每日一次用药方案治疗非复杂性多药耐药恶性疟的随机对照研究。
Clin Infect Dis. 2005 Aug 15;41(4):425-32. doi: 10.1086/432011. Epub 2005 Jul 15.

越南受试者中双氢青蒿素和哌喹两种固定剂量片剂剂型的药代动力学和生物等效性评价。

Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects.

作者信息

Chinh Nguyen Trong, Quang Nguyen Ngoc, Thanh Nguyen Xuan, Dai Bui, Geue Jason P, Addison Russell S, Travers Thomas, Edstein Michael D

机构信息

Department of Infectious Diseases, Military Hospital, Hanoi, Vietnam.

出版信息

Antimicrob Agents Chemother. 2009 Feb;53(2):828-31. doi: 10.1128/AAC.00927-08. Epub 2008 Dec 1.

DOI:10.1128/AAC.00927-08
PMID:19047656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2630617/
Abstract

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.

摘要

在健康的越南受试者中，发现双氢青蒿素和哌喹的两种固定剂量组合（Artekin和Arterakine）生物不等效。然而，由于两种制剂之间双氢青蒿素和哌喹的血浆峰浓度和浓度-时间曲线下面积仅略有差异，预计在治疗疟疾感染时具有相似的治疗效果。