成熟T细胞重返胸腺：一种附带现象？
Re-entry of mature T cells to the thymus: an epiphenomenon?
作者信息
Sprent Jonathan, Surh Charles D
机构信息
Department of Immunology, The Garvan Institute of Medical Research, Sydney, Australia.
出版信息
Immunol Cell Biol. 2009 Jan;87(1):46-9. doi: 10.1038/icb.2008.88. Epub 2008 Dec 2.
Abstract
In certain situations mature post-thymic T cells are able to leave their residence in the secondary lymphoid tissues and re-enter the thymus. The physiological significance of this phenomenon is discussed.
摘要
在某些情况下，成熟的胸腺后T细胞能够离开它们在次级淋巴组织中的驻留位置，重新进入胸腺。本文讨论了这一现象的生理学意义。
相似文献
1
Re-entry of mature T cells to the thymus: an epiphenomenon?成熟T细胞重返胸腺：一种附带现象？
Immunol Cell Biol. 2009 Jan;87(1):46-9. doi: 10.1038/icb.2008.88. Epub 2008 Dec 2.
2
Thymic re-entry of mature activated T cells and increased negative selection in vascularized allograft recipients.成熟活化T细胞的胸腺再进入及血管化同种异体移植受者中阴性选择增加。
Clin Exp Immunol. 2002 Jan;127(1):43-52. doi: 10.1046/j.1365-2249.2002.01717.x.
3
Peripheral T cells in the thymus: have they just lost their way or do they do something?胸腺中的外周T细胞：它们只是迷路了还是有所作为？
Immunol Cell Biol. 2009 Jan;87(1):50-7. doi: 10.1038/icb.2008.83.
4
The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs.胸腺输出的长寿、完全定向的T细胞前体能够在初级淋巴器官中定植。
Nat Immunol. 2006 Jan;7(1):76-82. doi: 10.1038/ni1293. Epub 2005 Dec 11.
5
Back to the thymus: peripheral T cells come home.回到胸腺：外周T细胞归巢。
Immunol Cell Biol. 2009 Jan;87(1):58-64. doi: 10.1038/icb.2008.87. Epub 2008 Nov 25.
6
Zoned out: functional mapping of stromal signaling microenvironments in the thymus.注意力分散：胸腺中基质信号微环境的功能图谱
Annu Rev Immunol. 2007;25:649-79. doi: 10.1146/annurev.immunol.23.021704.115715.
7
The role of the reticulo-epithelial (RE) cell network in the immuno-neuroendocrine regulation of intrathymic lymphopoiesis.网状上皮（RE）细胞网络在胸腺内淋巴细胞生成的免疫-神经内分泌调节中的作用。
Anticancer Res. 2000 May-Jun;20(3A):1871-88.
8
Intrathymic Cell Migration: Implications in Thymocyte Development and T Lymphocyte Repertoire Formation.胸腺内细胞迁移：对胸腺细胞发育和T淋巴细胞库形成的影响
Adv Exp Med Biol. 2025;1471:139-175. doi: 10.1007/978-3-031-77921-3_5.
9
Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse.小鼠T细胞缺陷品系（CTS）中胸腺细胞迁出缺陷
J Immunol. 1996 Oct 15;157(8):3412-9.
10
Finding their niche: chemokines directing cell migration in the thymus.找到自己的位置：趋化因子在胸腺中引导细胞迁移。
Immunol Cell Biol. 2011 Feb;89(2):185-96. doi: 10.1038/icb.2010.142. Epub 2010 Dec 7.
引用本文的文献
1
The unilateral involution in the thymus of a 96-year-old male leads to the preservation of structural integrity in one thymic lobe, as assessed by the expression of medullar and cortical antigens and the presence of CD3+ cells.一名96岁男性胸腺的单侧退化，导致一个胸腺叶的结构完整性得以保留，这是通过髓质和皮质抗原的表达以及CD3+细胞的存在来评估的。
Heliyon. 2022 Nov 17;8(11):e11734. doi: 10.1016/j.heliyon.2022.e11734. eCollection 2022 Nov.
2
The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation.恰加斯病中的胸腺：异常 T 细胞迁移和分化涉及的分子相互作用。
Front Immunol. 2020 Sep 2;11:1838. doi: 10.3389/fimmu.2020.01838. eCollection 2020.
3
Th1 Biased Progressive Autoimmunity in Aged Deficient Mice Accelerated Thymic Epithelial Cell Senescence.衰老缺陷小鼠中偏向Th1的进行性自身免疫加速胸腺上皮细胞衰老。
Aging Dis. 2019 Jun 1;10(3):497-509. doi: 10.14336/AD.2018.0608. eCollection 2019 Jun.
4
Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8+ T cell development.全身性炎症或感染性 Th1 疾病过程后，胸腺中 IL-4 和 IL-15 的表达在 CD8+T 细胞发育过程中诱导获得“先天”特性。
PLoS Pathog. 2019 Jan 4;15(1):e1007456. doi: 10.1371/journal.ppat.1007456. eCollection 2019 Jan.
5
Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions.激素信号通路在恰加斯病T细胞发育中的作用：对T细胞功能障碍的潜在影响
Front Endocrinol (Lausanne). 2018 Jun 14;9:334. doi: 10.3389/fendo.2018.00334. eCollection 2018.
6
Specialized proteasome subunits have an essential role in the thymic selection of CD8(+) T cells.专门的蛋白酶体亚基在CD8(+) T细胞的胸腺选择中起关键作用。
Nat Immunol. 2016 Aug;17(8):938-45. doi: 10.1038/ni.3480. Epub 2016 Jun 13.
7
Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment.克氏锥虫实验性感染对胸腺调节性T细胞区室的影响。
PLoS Negl Trop Dis. 2016 Jan 8;10(1):e0004285. doi: 10.1371/journal.pntd.0004285. eCollection 2016 Jan.
8
Dynamics of HIV infection in lymphoid tissue network.HIV在淋巴组织网络中的感染动态。
J Math Biol. 2016 Mar;72(4):909-938. doi: 10.1007/s00285-015-0940-x. Epub 2015 Oct 27.
9
T cells home to the thymus and control infection.T 细胞归巢到胸腺并控制感染。
J Immunol. 2013 Feb 15;190(4):1646-58. doi: 10.4049/jimmunol.1202412. Epub 2013 Jan 11.
10
Immature CD4+CD8+ thymocytes are preferentially infected by measles virus in human thymic organ cultures.人胸腺器官培养中，未成熟的 CD4+CD8+胸腺细胞优先被麻疹病毒感染。
PLoS One. 2012;7(9):e45999. doi: 10.1371/journal.pone.0045999. Epub 2012 Sep 24.
本文引用的文献
1
Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.循环回到胸腺的外周T淋巴细胞可介导胸腺细胞阳性选择。
J Immunol. 2008 Jul 15;181(2):1207-14. doi: 10.4049/jimmunol.181.2.1207.
2
Shaping and reshaping CD8+ T-cell memory.塑造和重塑CD8+T细胞记忆。
Nat Rev Immunol. 2008 Feb;8(2):107-19. doi: 10.1038/nri2251.
3
The highway code of T cell trafficking.T细胞迁移的规则
J Pathol. 2008 Jan;214(2):179-89. doi: 10.1002/path.2269.
4
Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.白细胞介素-2受体对胸腺及外周CD4+CD25+Foxp3+调节性T细胞的作用。
J Immunol. 2007 Apr 1;178(7):4062-71. doi: 10.4049/jimmunol.178.7.4062.
5
Peripheral T cell lymphopenia and concomitant enrichment in naturally arising regulatory T cells: the case of the pre-Talpha gene-deleted mouse.外周T细胞淋巴细胞减少以及自然产生的调节性T细胞同时富集：pre-Tα基因缺失小鼠的情况。
J Immunol. 2006 Oct 15;177(8):5014-23. doi: 10.4049/jimmunol.177.8.5014.
6
The role of the transcription factor Foxp3 in the development of regulatory T cells.转录因子Foxp3在调节性T细胞发育中的作用。
Immunol Rev. 2006 Aug;212:86-98. doi: 10.1111/j.0105-2896.2006.00426.x.
7
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease.Foxp3 + CD25 + CD4 + 自然调节性T细胞在显性自身耐受和自身免疫性疾病中的作用
Immunol Rev. 2006 Aug;212:8-27. doi: 10.1111/j.0105-2896.2006.00427.x.
8
Thymic output in aged mice.老年小鼠的胸腺输出。
Proc Natl Acad Sci U S A. 2006 May 30;103(22):8447-52. doi: 10.1073/pnas.0601040103. Epub 2006 May 22.
9
Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.有证据表明，大量初始T细胞作为正常迁移途径的一部分进入非淋巴器官。
Eur J Immunol. 2006 Jun;36(6):1423-33. doi: 10.1002/eji.200535539.
10
T-cell homing specificity and plasticity: new concepts and future challenges.T细胞归巢特异性与可塑性：新概念与未来挑战
Trends Immunol. 2006 May;27(5):235-43. doi: 10.1016/j.it.2006.03.007. Epub 2006 Mar 31.
Zotero 插件