Etuwewe Bemigho, Jones Caroline A, Mathur Shipra, Wright Katherine P, Morris Andrew A M
Department of Nephrology, Royal Liverpool Children's Hospital, Liverpool, UK.
Pediatr Nephrol. 2009 May;24(5):1085-7. doi: 10.1007/s00467-008-1068-7. Epub 2008 Dec 2.
Chronic renal failure is a common complication of methylmalonic acidaemia (MMA). It is usually managed with haemodialysis and renal transplantation. We report the use of continuous cycling peritoneal dialysis (CCPD) for 20 months in a paediatric patient with chronic renal failure due to MMA. This procedure resulted in the elimination of 950 micromol methylmalonate (MM) per day and a fall in the plasma MM concentration from 3.9 to 0.74 mmol/l. As a result of this treatment, the frequency at which this patient was hospitalised was markedly reduced prior to a successful renal transplantation.
慢性肾衰竭是甲基丙二酸血症（MMA）的常见并发症。通常采用血液透析和肾移植进行治疗。我们报告了一名因MMA导致慢性肾衰竭的儿科患者接受持续循环腹膜透析（CCPD）20个月的情况。该治疗方法每天可清除950微摩尔甲基丙二酸（MM），血浆MM浓度从3.9毫摩尔/升降至0.74毫摩尔/升。由于这种治疗，该患者在成功进行肾移植之前的住院频率显著降低。
