Buesa J M, Fernández R, Esteban E, Estrada E, Barón F J, Palacio I, Gracia M, Lacave A J
Servicio de Oncología Médica, Hospital General de Asturias, Oviedo, Spain.
Ann Oncol. 1991 Feb;2(2):151-2. doi: 10.1093/oxfordjournals.annonc.a057880.
Thirty-six patients with recurrent carcinoma of the head and neck and no prior exposure to chemotherapy were treated with Ifosfamide. This drug was administered, concomitantly with Mesna, as a 24-hr infusion at a dose of 5-6.25 g/m2 every 3 weeks. Objective activity in 32 evaluable patients was 28% (9/32, 95% C.I. 17%-39%); 40% of patients had leukocyte values less than 2000 mm3 and 6% platelets less than 50,000 mm3. Nonhematologic toxicity consisted mainly of nausea/vomiting (66% greater than or equal to grade 2) and alopecia (80% greater than or equal to grade 2). The activity encountered warrants further studies with this drug in head and neck cancer.
36例复发性头颈癌患者且此前未接受过化疗，接受了异环磷酰胺治疗。该药物与美司钠同时给药，每3周以5 - 6.25 g/m²的剂量进行24小时输注。32例可评估患者的客观有效率为28%（9/32，95%置信区间17% - 39%）；40%的患者白细胞值低于2000/mm³，6%的患者血小板低于50,000/mm³。非血液学毒性主要包括恶心/呕吐（66%≥2级）和脱发（80%≥2级）。所观察到的疗效表明有必要对该药物在头颈癌治疗中进行进一步研究。
