Weiss A J, Stambaugh J E, Mastrangelo M J, Laucius J F, Bellet R E
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Cancer Chemother Rep. 1972 Jun;56(3):413-9.
Thirty patients with various solid tumors were treated with 5-azacytidine. Total doses ranged from 1.0 to 24.0 mg/kg and were given over a minimal period of 8 days. The major toxic effect was hematologic with significant leukopenia and thrombocytopenia usually occurring 20-30 days after the start of therapy, especially at higher dose levels. The marrow depression lasted 1-5 weeks and was fully reversible. Nausea and mild diarrhea were common following injection of the drug. Serum glutamic oxaloacetic transaminase levels rose in several patients. No other evidence of hepatic toxicity was seen. Objective remissions were noted in seven of 11 patients with cancer of the breast, two of five with melanoma, and two of six with cancer of the colon.
30例患有各种实体瘤的患者接受了5-氮杂胞苷治疗。总剂量范围为1.0至24.0mg/kg，给药时间最短为8天。主要毒性作用是血液学方面的，显著的白细胞减少和血小板减少通常在治疗开始后20至30天出现，尤其是在较高剂量水平时。骨髓抑制持续1至5周，且完全可逆。注射该药物后，恶心和轻度腹泻很常见。几名患者的血清谷草转氨酶水平升高。未发现其他肝毒性证据。在11例乳腺癌患者中有7例、5例黑色素瘤患者中有2例、6例结肠癌患者中有2例出现了客观缓解。
