• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis and studies on antibacterial activity of pyrido[3,2-e]-1,2-thiazines and related derivatives.

作者信息

Malinka Wiesław, Gamian Andrzej, Szcześniak-Siega Berenika

机构信息

Wrocław Medical University, Faculty of Pharmacy, 1 Tamka St., 50-137 Wrocław, Poland.

出版信息

Acta Pol Pharm. 2008 Sep-Oct;65(5):557-63.

PMID:19051602
Abstract

Twenty of the known and newly synthesized derivatives of pyrido-1,2-thiazine derivatives 3-7, which represent a novel class of potential antibacterial agents, were evaluated against strains of Mycobacterium fortuitum (PCM 672) and Staphylococcus aureus (PCM 2602). The pilot experiments showed that the compounds in an initial in vitro microbiological evaluation were not efficient antibacterial agents, whereas some of them unexpectedly promoted replication of the microorganisms in the range of 10-50% even at sub-mg/mL concentrations.

摘要

相似文献

1
Synthesis and studies on antibacterial activity of pyrido[3,2-e]-1,2-thiazines and related derivatives.
Acta Pol Pharm. 2008 Sep-Oct;65(5):557-63.
2
Pyrido-1,2-thiazines and their in vitro antibacterial evaluation.
Acta Pol Pharm. 2008 Jan-Feb;65(1):71-4.
3
Naphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: synthesis and biological evaluation as potential antibacterial and antifungal agents.萘并[2,3-b][1,4]-噻嗪-5,10-二酮及3-取代-1,4-二氧代-1,4-二氢萘-2-基硫代链烷酸酯衍生物：作为潜在抗菌和抗真菌剂的合成及生物学评价
Bioorg Med Chem Lett. 2006 Nov 15;16(22):5883-7. doi: 10.1016/j.bmcl.2006.08.060. Epub 2006 Sep 1.
4
Antimycobacterial activity of some pyrido-1,2-thiazine derivatives.某些吡啶并[1,2 - b]噻嗪衍生物的抗分枝杆菌活性
Acta Pol Pharm. 2002 Nov-Dec;59(6):439-42.
5
Synthesis of some substituted pyrido-[3,2-b] [1,4]-benzothiazines and their antibacterial activity.
Pharmazie. 1991 Oct;46(10):746-7.
6
Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles.含苯并咪唑杂环的新型放线菌素衍生物的设计、合成及抗菌活性
Eur J Med Chem. 2009 May;44(5):2202-10. doi: 10.1016/j.ejmech.2008.05.009. Epub 2008 May 23.
7
Cyclopentanone ring-cleaved pleuromutilin derivatives.环戊酮环裂解截短侧耳素衍生物
Eur J Med Chem. 2007 Jan;42(1):109-13. doi: 10.1016/j.ejmech.2006.07.018. Epub 2006 Dec 6.
8
Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives.N-（5-苄硫基-1,3,4-噻二唑-2-基）和N-（5-苄磺酰基-1,3,4-噻二唑-2-基）哌嗪基喹诺酮衍生物的合成及其抗菌活性
Bioorg Med Chem Lett. 2005 Oct 15;15(20):4488-92. doi: 10.1016/j.bmcl.2005.07.016.
9
Synthesis and antimicrobial studies of novel dichlorofluorophenyl containing aminotriazolothiadiazines.含二氯氟苯基的新型氨基三唑并噻二嗪的合成与抗菌研究
Eur J Med Chem. 2008 Feb;43(2):309-14. doi: 10.1016/j.ejmech.2007.03.024. Epub 2007 Apr 7.
10
Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives.N-去甲基万古霉素衍生物的固相合成及抗菌活性评价
Bioorg Med Chem Lett. 2005 May 2;15(9):2325-9. doi: 10.1016/j.bmcl.2005.02.086.