Irshaid Y, Gharaybeh K
Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid.
Pharmacol Toxicol. 1991 Mar;68(3):212-4. doi: 10.1111/j.1600-0773.1991.tb01225.x.
Glucuronidation of 7-hydroxy-4-methylcoumarin (7-H-4-MC) by microsomal UDP-glucuronosyltransferases from 12 human liver biopsy samples was studied. Glucuronidation rates were highest for livers with mild cholestasis while those for livers with mild fatty changes were similar to normal livers. The lowest rates were exhibited by livers showing primary or metastatic carcinoma on histological examination. Thus, glucuronidation of not only bile acids but also of other substrates such as 7-H-4-MC may be elevated in cholestasis. These results are also consistent with other studies stating that glucuronidation might be spared in certain mild hepatic diseases.
研究了来自12份人类肝脏活检样本的微粒体UDP-葡萄糖醛酸基转移酶对7-羟基-4-甲基香豆素（7-H-4-MC）的葡萄糖醛酸化作用。轻度胆汁淤积的肝脏葡萄糖醛酸化率最高，而轻度脂肪变性的肝脏葡萄糖醛酸化率与正常肝脏相似。组织学检查显示原发性或转移性癌的肝脏葡萄糖醛酸化率最低。因此，胆汁淤积时不仅胆汁酸的葡萄糖醛酸化，而且其他底物如7-H-4-MC的葡萄糖醛酸化可能会升高。这些结果也与其他研究一致，即某些轻度肝病中葡萄糖醛酸化可能未受影响。
