Li Xiu-Qin, Zhang Shu-Lan, Cai Zhen, Zhou Yuan, Ye Tian-Min, Chiu Jen-Fu
China Medical University Affiliated Shengjing Hospital, Shenyang 110004, China.
Cancer Lett. 2009 Mar 8;275(1):109-16. doi: 10.1016/j.canlet.2008.10.019. Epub 2008 Dec 3.
Ovarian epithelial serous cystadenocarcinoma (OESC) is the most lethal of all gynecologic malignancies. In this report, we performed comparative proteomic study of normal ovarian epithelial and OESC tissue in order to establish OESC related protein atlas, and to identify tumor-associated proteins which may be important target proteins for clinical diagnosis and therapy and/or closely correlated to OESC pathogenesis. Six proteins were found significantly differentially expressed between normal ovarian epithelial and OESC tissues. The marked expression differences of selected proteins were further confirmed by Western blotting and immunohistochemistry. The correlation of prx-II expression with clinico-pathological features was also investigated.
卵巢上皮性浆液性囊腺癌（OESC）是所有妇科恶性肿瘤中致死率最高的。在本报告中，我们对正常卵巢上皮组织和OESC组织进行了比较蛋白质组学研究，以建立与OESC相关的蛋白质图谱，并鉴定可能是临床诊断和治疗的重要靶蛋白和/或与OESC发病机制密切相关的肿瘤相关蛋白。我们发现正常卵巢上皮组织和OESC组织之间有6种蛋白质存在显著差异表达。通过蛋白质免疫印迹法和免疫组织化学进一步证实了所选蛋白质的明显表达差异。我们还研究了prx-II表达与临床病理特征的相关性。
