Johnsen Grethe E, Asbjørnsen Arve E
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
Psychiatry Res. 2009 Jan 30;165(1-2):68-77. doi: 10.1016/j.psychres.2008.01.001. Epub 2008 Dec 5.
The present study examined mechanisms underlying verbal memory impairments in patients with posttraumatic stress disorder (PTSD). Earlier studies have reported that the verbal learning and memory alterations in PTSD are related to impaired encoding, but the use of encoding and organizational strategies in patients with PTSD has not been fully explored. This study examined organizational strategies in 21 refugees/immigrants exposed to war and political violence who fulfilled DSM-IV criteria for chronic PTSD compared with a control sample of 21 refugees/immigrants with similar exposure, but without PTSD. The California Verbal Learning Test was administered to examine differences in organizational strategies and memory. The semantic clustering score was slightly reduced in both groups, but the serial cluster score was significantly impaired in the PTSD group and they also reported more items from the recency region of the list. In addition, intrusive errors were significantly increased in the PTSD group. The data support an assumption of changed memory strategies in patients with PTSD associated with a specific impairment in executive control. However, memory impairment and the use of ineffective learning strategies may not be related to PTSD symptomatology only, but also to self-reported symptoms of depression and general distress.
本研究探讨了创伤后应激障碍(PTSD)患者言语记忆受损的潜在机制。早期研究报告称,PTSD患者的言语学习和记忆改变与编码受损有关,但PTSD患者对编码和组织策略的运用尚未得到充分探究。本研究对21名经历过战争和政治暴力且符合DSM-IV慢性PTSD标准的难民/移民的组织策略进行了研究,并与21名有类似经历但未患PTSD的难民/移民对照样本进行了比较。使用加利福尼亚言语学习测验来检验组织策略和记忆方面的差异。两组的语义聚类分数均略有降低,但PTSD组的系列聚类分数显著受损,且他们还报告了列表近期区域中的更多项目。此外,PTSD组的侵入性错误显著增加。数据支持这样一种假设,即PTSD患者的记忆策略发生了改变,这与执行控制方面的特定损伤有关。然而,记忆损伤和无效学习策略的使用可能不仅与PTSD症状有关,还与自我报告的抑郁症状和一般痛苦有关。