Geuze Elbert, Vermetten Eric, de Kloet Carien S, Hijman Ron, Westenberg Herman G M
Research Centre-Military Mental Health, Ministry of Defense, Utrecht, The Netherlands.
Depress Anxiety. 2009;26(1):7-15. doi: 10.1002/da.20476.
Several studies have reported deficits in both immediate and delayed recall of verbal memory in patients with posttraumatic stress disorder (PTSD). However, most of these studies had several methodological disadvantages. None of these studies assessed parameters related to social or occupational functioning.
Fifty Dutch veterans of UN peacekeeping missions (25 with PTSD and 25 without PTSD) were assessed with a comprehensive neuropsychological test battery consisting of four subtests of the Wechsler Adult Intelligence Scale-III, California Verbal-Learning Test, and the Rey Auditory Verbal-Learning Test. Veterans with PTSD were free of medication and substance abuse.
Veterans with PTSD had similar total intelligence quotient scores compared to controls, but displayed deficits of figural and logical memory. Veterans with PTSD also performed significantly lower on measures of learning and immediate and delayed verbal memory. Memory performance accurately predicted current social and occupational functioning.
Deficits of memory performance were displayed in a sample of medication- and substance abuse-free veterans with PTSD. Deficits in memory performance were not related to intelligence quotient, length of trauma exposure, or time since trauma exposure. This study showed that cognitive performance accurately predicted current social and occupational functioning in veterans with PTSD.
多项研究报告称,创伤后应激障碍(PTSD)患者在言语记忆的即时回忆和延迟回忆方面均存在缺陷。然而,这些研究大多存在一些方法学上的缺点。这些研究均未评估与社会或职业功能相关的参数。
对50名荷兰联合国维和任务退伍军人(25名患有PTSD,25名未患PTSD)进行了全面的神经心理学测试,测试组合包括韦氏成人智力量表第三版的四个子测试、加利福尼亚言语学习测试和雷伊听觉言语学习测试。患有PTSD的退伍军人未服用药物且无药物滥用情况。
与对照组相比,患有PTSD的退伍军人的总智商得分相似,但在图形和逻辑记忆方面存在缺陷。患有PTSD的退伍军人在学习以及即时和延迟言语记忆测试中的表现也显著较低。记忆表现准确预测了当前的社会和职业功能。
在无药物和物质滥用的患有PTSD的退伍军人样本中表现出记忆表现缺陷。记忆表现缺陷与智商、创伤暴露时间或创伤暴露后的时间无关。这项研究表明,认知表现准确预测了患有PTSD的退伍军人当前的社会和职业功能。