烟酰胺腺嘌呤二核苷酸磷酸氧化酶与血管紧张素 II 受体信号传导。
NADPH oxidases and angiotensin II receptor signaling.
作者信息
Garrido Abel Martin, Griendling Kathy K
机构信息
Division of Cardiology, Emory University, Atlanta, GA 30322, USA.
出版信息
Mol Cell Endocrinol. 2009 Apr 29;302(2):148-58. doi: 10.1016/j.mce.2008.11.003. Epub 2008 Nov 18.
Abstract
Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin-angiotensin system.
摘要
在过去十年中，许多研究已经证明了NADPH氧化酶产生的活性氧（ROS）在血管紧张素II（Ang II）信号传导中的重要性，以及ROS在以Ang II为核心成分的不同疾病发展中的作用。在这篇综述中，我们总结了Ang II激活NADPH氧化酶的机制，并描述了ROS在血管、肾脏和大脑中Ang II信号传导中的分子靶点。我们还讨论了NADPH氧化酶功能的基因操作对肾素-血管紧张素系统生理和病理生理的影响。
相似文献
1
NADPH oxidases and angiotensin II receptor signaling.烟酰胺腺嘌呤二核苷酸磷酸氧化酶与血管紧张素 II 受体信号传导。
Mol Cell Endocrinol. 2009 Apr 29;302(2):148-58. doi: 10.1016/j.mce.2008.11.003. Epub 2008 Nov 18.
2
Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.Gα12/13介导的活性氧生成对于血管紧张素受体诱导的心脏成纤维细胞中NFAT激活至关重要。
J Biol Chem. 2005 Jun 17;280(24):23041-7. doi: 10.1074/jbc.M409397200. Epub 2005 Apr 12.
3
NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells.NADPH 氧化酶产生的 H(2)O(2)有助于血管紧张素 II 诱导的人及大鼠肾上腺皮质细胞醛固酮的合成。
Antioxid Redox Signal. 2012 Aug 1;17(3):445-59. doi: 10.1089/ars.2011.4176. Epub 2012 Mar 2.
4
Angiotensin II, NADPH oxidase, and redox signaling in the vasculature.血管中的血管紧张素 II、NADPH 氧化酶和氧化还原信号。
Antioxid Redox Signal. 2013 Oct 1;19(10):1110-20. doi: 10.1089/ars.2012.4641. Epub 2012 Jun 11.
5
(Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells.(原)肾素受体介导神经元细胞中血管紧张素 II 依赖性和非依赖性氧化应激。
PLoS One. 2013;8(3):e58339. doi: 10.1371/journal.pone.0058339. Epub 2013 Mar 14.
6
Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells.血管紧张素II诱导的NADPH氧化酶激活会损害骨骼肌细胞中的胰岛素信号传导。
J Biol Chem. 2006 Nov 17;281(46):35137-46. doi: 10.1074/jbc.M601320200. Epub 2006 Sep 17.
7
Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction.激活ACE2/血管紧张素-(1-7)/Mas通路可减轻因血管紧张素II过量产生而导致的氧糖剥夺诱导的小鼠脑组织肿胀、活性氧生成及细胞死亡。
Neuroscience. 2014 Jul 25;273:39-51. doi: 10.1016/j.neuroscience.2014.04.060. Epub 2014 May 9.
8
Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4.血管紧张素 II 通过 AT1 受体和 NADPH 氧化酶同工型 Nox4 诱导 DNA 损伤。
Mutagenesis. 2012 Nov;27(6):673-81. doi: 10.1093/mutage/ges033. Epub 2012 Jul 27.
9
Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence.源自NADPH氧化酶1和线粒体的活性氧介导血管紧张素II诱导的平滑肌细胞衰老。
J Mol Cell Cardiol. 2016 Sep;98:18-27. doi: 10.1016/j.yjmcc.2016.07.001. Epub 2016 Jul 2.
10
NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells.NADPH氧化酶1通过促进血管平滑肌细胞内钙内流介导对血管紧张素II的急性血压反应。
Arterioscler Thromb Vasc Biol. 2022 May;42(5):e117-e130. doi: 10.1161/ATVBAHA.121.317239. Epub 2022 Mar 31.
引用本文的文献
1
Bridging the gap between CVD and COVID-19: the oxidized LDL hypothesis.弥合心血管疾病与新冠病毒疾病之间的差距：氧化型低密度脂蛋白假说。
Front Med (Lausanne). 2025 Aug 6;12:1588062. doi: 10.3389/fmed.2025.1588062. eCollection 2025.
2
Angiotensin II and Cardiovascular Disease: Balancing Pathogenic and Protective Pathways.血管紧张素II与心血管疾病：平衡致病与保护途径
Curr Issues Mol Biol. 2025 Jul 1;47(7):501. doi: 10.3390/cimb47070501.
3
Chymase Inhibition Attenuates Kidney Fibrosis in a Chronic Mouse Model of Renal Ischemia-Reperfusion Injury.在慢性肾缺血-再灌注损伤小鼠模型中，糜酶抑制可减轻肾纤维化。
Int J Mol Sci. 2025 Apr 21;26(8):3913. doi: 10.3390/ijms26083913.
4
Exploring the Mechanism of Canmei Formula in Preventing and Treating Recurrence of Colorectal Adenoma Based on Data Mining and Algorithm Prediction.基于数据挖掘和算法预测探索参梅方防治大肠腺瘤复发的机制
Biol Proced Online. 2025 Feb 1;27(1):4. doi: 10.1186/s12575-025-00266-5.
5
Molecular Mechanisms Underlying Vascular Remodeling in Hypertension.高血压血管重塑的分子机制
Rev Cardiovasc Med. 2024 Feb 20;25(2):72. doi: 10.31083/j.rcm2502072. eCollection 2024 Feb.
6
Advancements in the neurocirculatory reflex response to hypoxia.神经循环反射对缺氧反应的研究进展。
Am J Physiol Regul Integr Comp Physiol. 2024 Jul 1;327(1):R1-R13. doi: 10.1152/ajpregu.00237.2023. Epub 2024 May 13.
7
The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension.天然抗氧化剂对与动脉高血压相关的内皮功能障碍的潜在影响。
Front Cardiovasc Med. 2024 Feb 2;11:1345218. doi: 10.3389/fcvm.2024.1345218. eCollection 2024.
8
The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer.局部血管紧张素 II/血管紧张素 1 型受体机制在促进胰腺癌的脂肪组织功能障碍中的作用。
Curr Cancer Drug Targets. 2024;24(12):1187-1194. doi: 10.2174/0115680096281059240103154836.
9
Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.综合方法减少老年人多药治疗：探索氧化应激和抗氧化潜能治疗的作用。
Redox Rep. 2024 Dec;29(1):2289740. doi: 10.1080/13510002.2023.2289740. Epub 2023 Dec 18.
10
The RAAS Goodfellas in Cardiovascular System.心血管系统中的肾素-血管紧张素-醛固酮系统（RAAS）“好家伙”
J Clin Med. 2023 Oct 31;12(21):6873. doi: 10.3390/jcm12216873.
本文引用的文献
1
Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.血管紧张素II的氧化还原敏感信号传导涉及自发性高血压大鼠血管平滑肌细胞中蛋白酪氨酸磷酸酶SHP-2的氧化失活和磷酸化减弱。
Circ Res. 2008 Jul 18;103(2):149-58. doi: 10.1161/CIRCRESAHA.108.178608. Epub 2008 Jun 19.
2
Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression.Nox4烟酰胺腺嘌呤二核苷酸磷酸氧化酶介导血管紧张素II诱导的依赖Src的丙酮酸脱氢酶激酶-1酪氨酸磷酸化：在系膜细胞肥大和纤连蛋白表达中的作用
J Biol Chem. 2008 Aug 29;283(35):24061-76. doi: 10.1074/jbc.M803964200. Epub 2008 Jun 16.
3
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.产生活性氧的Nox家族NADPH氧化酶的结构、调控与进化
FEBS J. 2008 Jul;275(13):3249-77. doi: 10.1111/j.1742-4658.2008.06488.x. Epub 2008 May 30.
4
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.超氧化物歧化酶1（SOD1）对于生长因子信号传导中H2O2介导的磷酸酶氧化和失活至关重要。
Proc Natl Acad Sci U S A. 2008 May 20;105(20):7147-52. doi: 10.1073/pnas.0709451105. Epub 2008 May 14.
5
Evidence for a superoxide permeability pathway in endosomal membranes.内体膜中超氧化物通透性途径的证据。
Mol Cell Biol. 2008 Jun;28(11):3700-12. doi: 10.1128/MCB.02038-07. Epub 2008 Mar 31.
6
Angiotensin II increases the expression of the transcription factor ETS-1 in mesangial cells.血管紧张素II可增加系膜细胞中转录因子ETS-1的表达。
Am J Physiol Renal Physiol. 2008 May;294(5):F1094-100. doi: 10.1152/ajprenal.00458.2007. Epub 2008 Mar 12.
7
AP-1-dependent transcriptional regulation of NADPH oxidase in human aortic smooth muscle cells: role of p22phox subunit.人主动脉平滑肌细胞中NADPH氧化酶的AP-1依赖性转录调控：p22phox亚基的作用
Arterioscler Thromb Vasc Biol. 2008 May;28(5):878-85. doi: 10.1161/ATVBAHA.108.163592. Epub 2008 Feb 28.
8
Kidney fibrosis in hypertensive rats: role of oxidative stress.高血压大鼠的肾纤维化：氧化应激的作用
Am J Nephrol. 2008;28(4):548-54. doi: 10.1159/000115289. Epub 2008 Feb 1.
9
Protein tyrosine phosphorylation and protein tyrosine nitration in redox signaling.氧化还原信号传导中的蛋白质酪氨酸磷酸化和蛋白质酪氨酸硝化作用。
Antioxid Redox Signal. 2008 May;10(5):843-89. doi: 10.1089/ars.2007.1853.
10
Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension.在血管紧张素 II 依赖性慢性高血压中，Nox1 基因敲除可减弱肾脏氧化还原敏感信号传导，但不会降低血压。
Hypertension. 2008 Feb;51(2):500-6. doi: 10.1161/HYPERTENSIONAHA.107.103192. Epub 2008 Jan 14.
Zotero 插件