Garrido Abel Martin, Griendling Kathy K
Division of Cardiology, Emory University, Atlanta, GA 30322, USA.
Mol Cell Endocrinol. 2009 Apr 29;302(2):148-58. doi: 10.1016/j.mce.2008.11.003. Epub 2008 Nov 18.
Over the last decade many studies have demonstrated the importance of reactive oxygen species (ROS) production by NADPH oxidases in angiotensin II (Ang II) signaling, as well as a role for ROS in the development of different diseases in which Ang II is a central component. In this review, we summarize the mechanism of activation of NADPH oxidases by Ang II and describe the molecular targets of ROS in Ang II signaling in the vasculature, kidney and brain. We also discuss the effects of genetic manipulation of NADPH oxidase function on the physiology and pathophysiology of the renin-angiotensin system.
在过去十年中，许多研究已经证明了NADPH氧化酶产生的活性氧（ROS）在血管紧张素II（Ang II）信号传导中的重要性，以及ROS在以Ang II为核心成分的不同疾病发展中的作用。在这篇综述中，我们总结了Ang II激活NADPH氧化酶的机制，并描述了ROS在血管、肾脏和大脑中Ang II信号传导中的分子靶点。我们还讨论了NADPH氧化酶功能的基因操作对肾素-血管紧张素系统生理和病理生理的影响。
